RTK and GPCR Flashcards
1
Q
Which receptor type mediates a variety of growth factors as well as insulin?
A
RTK
2
Q
Which growth factor is a monomer?
A
Epidermal
3
Q
Which domains bind RTK?
A
SH2 and PTB
4
Q
PH domain
A
Binds lipids, like PIP2 and PIP3
5
Q
Grb2 domains
A
SH2-SH3-SH2
6
Q
Role of SOS
A
GEF
7
Q
Order of kinases in MAPK pathway
A
RAF, MEK, ERK
8
Q
Mechanisms to inactivate MAPK
A
- Spontaneous hydrolysis of GTP to GDP inactivates Ras
- RAS-GAP
- protein phosphatase
- Internalization of the receptor
9
Q
PI3 kinase subunits
A
p85 with two SH2 domains
p110 with Ras-GTP binding domain
10
Q
AKT domains
A
PH and kinase, which is inactive under basal conditions.
11
Q
Where does PDK phosphorylate AKT?
A
Threonine residue
12
Q
Where does TORC2 phosphorylate AKT?
A
Serine residue
13
Q
What is TOR?
A
Ser/Thr protein kinase
14
Q
What role does mTORC1 do in humans?
A
Increases cell growth by stimulating protein synthesis
15
Q
Rheb
A
Ras homolog which activates mTORC1 when in Rheb-GTP form
