RTA Flashcards
1
Q
What type of anion gap is associated with RTA
A
Normal anion gap - Hyperchloraemic metabolic acidosis
2
Q
Type 1 RTA features
A
Distal
- inability to general acid urine (secrete H+) in distal tubule
Causes hypokalaemia
complications include nephrocalcinosis and renal stones
Idiopathic, rheumatoid arthritis, SLE, sjogren’ s amphotericin B toxicity, analgesis nephropathy
3
Q
Type 2 RTA (proximal)
A
- Decreased HCO3- reabsorption in proximal tubule
Causes hypokalaemia
Complications include osteomalacia
Causes include idiopathic, Fanconi syndrome, wilson’s, carbonic anhydrase inhibitors- topiramate
4
Q
Type 3 RTA
A
Extremely rare
Carbonic anhydrase deficiency
Results in hypokalaemia
5
Q
Type 4 RTA
A
(hyperkalaemic)
reduction in aldosterone leads in turn to a reduction in proximal tubular ammonium excretion
causes hyperkalaemia
causes include hypoaldosteronism, diabetes