RSI Meds and Doses Flashcards
RSI Meds and Doses
RSI Preparation
BLESSED B BVM Laryngoscope ET-Tube Syringe Stylet Suction End-Tidal CO2 Drugs Backup
RSI Meds and Doses
Female ET Tube
Females: 7.5 ET max, inflate 4ml, 18 cm
RSI Meds and Doses
Male ET Tube
Males: 8 ET max, inflate 5 ml, 20 cm
RSI Meds and Doses
Difficult to bag:
Mask seal, obesity, age > 55, no teeth, stiff lungs
RSI Meds and Doses
Difficult to tube:
Look, eval 3-3-2, mallampati, obstruction, neck mobility
RSI Meds and Doses
Difficult to cric:
Surgery, hematoma/abscess, radiation, neck tumor/trauma
RSI Meds and Doses
Preoxygenation/denitrogenation:
100% FiO2 x 3 min or 8 VC breaths (non rebreather)- put nasal cannula on underneath. Consider CPAP mask or PEEP valve if unable to get O2 sat > 95%
RSI Meds and Doses
Pretreatment
Lidocaine:
1.5mg/kg IV (for head trauma, increased ICP, bronchospasm, asthma)
RSI Meds and Doses
Pretreatmentfor ICP, cardiac ischemia, aortic dissection
Fentanyl:
3 mcg/kg IV over 1-2 min (for ICP, cardiac ischemia, aortic dissection)
- best option for increased ICP
- caution: respiratory depression, hypotension, chest wall rigidity
RSI Meds and Doses
Pretreatment
Atropine (for peds with bradycardia)
0.01-0.02 mg/kg IV
RSI Meds and Doses
Pretreatment
Paralytic:
Roc 1mg/kg or Vec 0.1 mg/kg (defasciculation) if using sux - wait 2 min
In ICP if HTN use nicardipine, use hypertonic saline (250 ml over 10-15 min)
RSI Meds and Doses
Etomidate
0.3mg/kg IV- 20 mg- onset <1 min, duration 10-20 min- nonbarbiturate hypnotic
Protects from myocardial and cerebral ischemia, causes minimal histamine release
Benefits: less change to hemodynamics, decrease ICP, decrease intraocular pressure
Caveats: Myoclonic jerking, seizures, vomiting, no analgesia, decreased cortisol
Caution: in septic patients (adrenals)
RSI Meds and Doses
Propofol
2mg/kg IV over 1 min- 150 mg- onset 20-40s, duration 8-15 min- lipophilic
Myocardial depression and vasodilation
Benefits: antiemetic, anticonvulsant, decrease ICP
Caveats: hypotension, apnea, no analgesia
RSI Meds and Doses
Ketamine
2mg/kg IV- 140 mg onset-1 min, duration 10-20min- phencyclidine derivative
Preserves respiratory drive (awake intubation), direct smooth muscle relaxation and bronchodilation (refractory status asthmaticus)
- not prefered in elderly or patients with risk of
Cardiac ischemia
Benefits: bronchodilator, dissociative amnesia, analgesia (good in hypotensive and TBI)
Caveats: HTN, tachy (catecholamine release), laryngospasm, increase secretions, emergence phenomenon
RSI Meds and Doses
Ketofol
(100 mg ketamine, 100 mg propofol to make 20 ml)- 0.2 ml/kg- 14ml
RSI Meds and Doses
Versed
0.3mg/kg IV- hypotension
RSI Meds and Doses
Succinylcholine
1.5mg/kg IV (2 mg/kg in peds) onset 45-60 s, duration- 5-9 min(avoid in ICP)
Depolarizing neuromuscular blocker- high affinity for cholinergic receptors, resistant to
acetylcholinesterase
Contraindications: malignant hyperthermia, strokes with hemiparesis > 72 hrs, ICU stay > 2 weeks, burns/trauma> 72
hours, NMI disease, myopathies/muscular dystrophies, preexisting hyperkalemia, guillain-barre, severe infection > 5d
Complications: fasciculations, transient increased intragastric, intraocular and ICP, masseter spasm alone or with
malignant hyperthermia, bradycardia, prolonged apnea with pseudocholinesterase deficiency or myasthenia gravis,
serum K will rise 0.5 mEq/L
Malignant hyperthermia- rapid fever, muscle rigidity, acidosis, hyperkalemia- treat with dantrolene (2.5mg/kg)
RSI Meds and Doses
Rocuronium
1mg/kg IV onset 1-3 min, duration 30-45 min
Nondepolarizing neuromuscular blocker- compete with acetylcholine for cholinergic receptors , can be antagonized by anticholinesterase
Complication: tachycardia, long duration of action
Reversal: sugammadex- 2-4mg/kg- encapsulates drug Neostigmine (cholinesterase inhibitor)- can give with glycopyrrolate
RSI Meds and Doses
Vecuronium
0.1mg/kg IV onset 2-4 min, duration 25-40 min
Complication: prolonged recovery time in obese, elderly or hepatorenal dysfunction, hypotension
RSI Meds and Doses
Position:
Bed, axes, Sellick, BURP, DL–Face parallel, ears/notch, 30 degree Heads-up, collar plan
RSI Meds and Doses
Placement & confirmation:
Visualize thru cords, BL LS, fog in tube, EtCO2, capnography, CXR, US
RSI Meds and Doses
Post-tube mgmt:
Distance@teeth, tube secured, recheck BS & VS, vent settings, NGT, CXR, ABG after 10 min, sedate, vent settings.
RSI Meds and Doses
Vent settings:
Assist control-volume
Vt (protection)- 6-8 cc/kg PBW
IFR/flow rate (comfort)- 60-80 lpm
RR (ventilation)- initial 18- titrate based off CO2 (if acidotic may have to increase)
FiO2/PEEP (oxygenation)- Start at 100% and PEEP 0-5, wait 5 minutes draw ABG, titrate
goals: PaO2 55-90 mmHg, SpO2 88-95% PaCO2 40 mm Hg, FiO2 40-60%
check plateau pressure: <30, if higher lower Vt
In obstructive patients: increase expiratory time, permissive hypercapnia
IFR- 80-100, PEEP 0, RR 10 to start (I:E 1:4-5)
RSI Meds and Doses
Post Intubation Analgo-sedation:
Titrate to calm, spontaneously breathing
Fentanyl 2 mcg/kg bolus then 1 mcg/kg/hr
hydromorphone 0.5-1 mg bolus then q10min till effect and
Midazolam 0.05 mg/kg bolus then 0.025 mg/kg/hr
propofol 0.5mg/kg bolus then 20 mcg/kg/hr
Propofol infusion syndrome-metabolic acidosis, bradycardia, hyperlipidemia,hepatomegaly
Rhabdomyolysis, green urine
ketamine 1 mg/kg bolus then 0.5 mcg kg/hr
