RPGN & CRESCENTIC GN

Question 1

Refers to a clinical syndrome characterized by a rapid loss of kidney function, often accompanied by oliguria or anuria and features of glomerulonephritis, including dysmorphic erythrocyturia, erythrocyte cylindruria, and glomerular proteinuria

Answer 1

RPGN

Question 2

RPGN is also synonymous with?

Answer 2

CRESENTIC GN

Question 3

What is the most aggressive structural phenotype that results from glomerular inflammation?

Answer 3

CRESENTIC GN

Question 4

Results from focal rupture of glomerular capillary walls that allows inflammatory mediators and leukocytes to enter Bowman’s space, where they induce epithelial cell proliferation and macrophage influx and maturation

Answer 4

CELLULAR CRESCENTS

Question 5

What are the 3 diseases that can cause RPGN?

Answer 5

1. CRESCENTIC GN
2. ACUTE TMA
3. ATHEROEMBOLIC KIDNEY DISEASE

Question 6

What are the 3 major immunopathologic categories of crescentic GN?

Answer 6

1. IMMUNE COMPLEX CGN & C3 CGN
2. ANTI-GBM GN
3. PAUCI-IMMUNE GN

Question 7

What type of RPGN is caused by immune complex localization within glomeruli?

Answer 7

IMMUNE COMPLEX CRESCENTIC GN

Question 8

What is the most common cause of RPGN in children?

Answer 8

IMMUNE COMPLEX CRESCENTIC GN

Question 9

What type of RPGN shows little or no evidence of the localization of immune complex or anti-GBM antibodies in glomeruli?

Answer 9

PAUCI-IMMUNE CRESCENTIC GN

Question 10

What type of RPGN is usually associated with the presence of ANCAs?

Answer 10

PAUCI-IMMUNE GN

Question 11

What is the most common cause of RPGN and crescentic glomerulonephritis in older adults?

Answer 11

PAUCI-IMMUNE GN

Question 12

What type of RPGN is a component of a systemic small-vessel vasculitis (GPA, MPA, EGPA); however, some patients have renal-limited (primary) disease

Answer 12

PAUCI-IMMUNE GN

Question 13

What is the least frequent cause of Crescentic GN?

Answer 13

ANTI-GBM DISEASE