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Ch 31 Primary GN > IgA NEPHROPATHY > Flashcards

IgA NEPHROPATHY Flashcards

1
Q

Where is the location of IgA staining in IgA nephropathy?

A

MESANGIAL

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2
Q

What are the staining patterns in IgAN?

A

IgA - 100%
IgM - 84%
IgG - 62%
C3 - substantial staining in all
C1q - rare & weak
Gamma light chains&raquo_space;> Kappa

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3
Q

What is a distinctive feature of IgA nephropathy that is unlike any other glomerular immune complex disease

A

Immune deposits have more intense staining for GAMMA light chains than kappa light chains

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4
Q

Mildest LM findings in IgA nephropathy is analogous to what class of LN?

A

Class 2

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5
Q

More severe LM findings in IgA Nephropathy is analogous to what class of LN?

A

Class 3 & 4

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6
Q

What are the 4 parameters in Oxford classification that is independently predictive of clinical outcomes?

A

M - mesangial hypercellularity
E - endocapillary hypercellularity
S - segmental glomerulosclerosis
T - tubular atrophy-interstitial fibrosis

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7
Q

Which of the 4 parameters in the Oxford classification is significantly associated woth ESKD?

A

M - Mesangial Hypercellularity

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8
Q

Which of the 4 parameters in the Oxford classification is significantly associated with decline in kidney function?

A

S - Segmental glomerulosclerosis

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9
Q

Which of the 4 parameters in the Oxford classification is associated with both rate of decline & ESKD or a 50% decline in kidney function?

A

T - Tubular atrophy/interstitial fibrosis

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10
Q

Which of the 4 parameters in the Oxford classification is not predictive in the decline of kidney function or survival from ESKD or a 50% decline in kidney function?

A

E - Endocapillary hypercellularity

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11
Q

Which type of lesion in IgA nephropathy is responsive to immunosuppressive therapy?

A

E - Endocapillary hypercwllularity

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12
Q

Which parameters in Oxford classification are strongly associated with progression to kidney failure?

A

M - Mesangial hypercellularity
S - segmental glomerulosclerosis
T - tubular atrophy/interstitial fibrosis
C - crescents

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13
Q

What is the characteristic pathologic finding by IF in IgA nephropathy?

A

Granular deposits of IgA & C3 in the mesangium

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14
Q

What is term for the synchronous association of pharyngitis and macroscopic hematuria?

A

SYNPHARYNGITIC NEPHRITIS

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15
Q

What are the 2 types of IgA nephropathy?

A
  1. IDIOPATHIC
  2. SECONDARY
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16
Q

What protein excretion rate in IgA nephropathy is treatment indicated?

A

0.5 g/day

17
Q

What are the 3 evidence-based treatment for IgA nephropathy?

A
  1. RAAS BLOCKADE
  2. GLUCOCORTICOIDS (oral/IV)
  3. IMMUNOSUPPRESSIVE/CYTOTOXIC THERAPY (combination)

Ch 31 Primary GN (10 decks)

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