RPGN

Question 1

RPGN due to anti GBM disease is putup for renal transplant if they are dialysis dependant for

Answer 1

2 weeks

Question 2

essential feature of mixed cryoglobulinemia

Answer 2

low C4

Question 3

risk of relapse based on ANCA

Answer 3

MPO: less relapse
PR3: more relapse

Question 4

Malignancies after cyclophosphamide

Answer 4

bladder cancer

Hematological

Question 5

Antibody titres and candidacy for transplant in RPGN

Answer 5

Anti GBM: should be ELISA negative

AAV: ANCA titres have no significance

Question 6

Antigen target in anti GBM disease

Answer 6

α3 NC1 domain of collagen IV

Question 7

Age distribution of goodpasture?

Answer 7

Bimodal
young men in 20s
men and women in 60s and 70s

Question 8

Risk factor for hemoptysis in goodpasture?

Answer 8

smoking

Question 9

ANCA antibodies in goodpasture

Answer 9

good prognosis with Rx

Question 10

new antibodies in AAV

Answer 10

lamp 2

Question 11

Risk factors for GPA

Answer 11

silica dust

alpha 1 antitrypsin deficiency

Question 12

Difference btw GPA and MPA

Answer 12

MPA:
no significant lung involvement
no destructive sinusitis
no granuloma