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Liver > Rodriguez Notes > Flashcards

Rodriguez Notes Flashcards

1
Q

What conditions are indicative of Liver Disease?

A

Jaundice
Portal Hypertension
Disordered Homeostasis
Release of Enzymes into body fluid
Jake Pawns DRums

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2
Q

What is the most specific clinical manifestation of Hepatic Dysfunction?

A

Jaundice
Not present in many individuals with Liver Disease

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3
Q

How do we store a Jaundice Specimen?

A

Seperated from cells
2 days at room temp
1 week at 4C
Forever at -20C

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4
Q

When does Portal Hypertension occur?

A

Obstruction to portal flow anywhere along its course

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5
Q

What causes the majority of Portal Hypertension?

A

Cirrhosis

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6
Q

What is one the leading causes of morbidity and mortality in patients with Cirrhosis?

A

Bleeding from Varices

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7
Q

What are the factors that govern the ability of Liver Enzymes to assist in diagnosis?

A

Tissue Specificity
Subcellular Distribution
Enzyme Activity
Patterns of release
Clearance from plasma
This Shrine Eats People like Candy

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8
Q

What are the two major components of Chronic Hepatitis?

A

Fibrosis and Necroinflammatory Activity

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9
Q

Which Hepatitis requires a vaccination?

A

Hepatitis B
Body fluids (Parenteral/Vertical)
DNA virus

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10
Q

What is important about HBsAg (Hepatitis B surface Antigen)?

A

Detects current HBV infection
First serological marker to appear and last to dissapear

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11
Q

What is an RNA Flavivirus with a high rate of mutation?

A

Hepatitis C
Injection drug use

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12
Q

What percentage is HCV infection responsible for Acute Hepatitis?

A

10%-15%

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13
Q

What is used to detect active infection of Hepatitis C?

A

HCV RNA

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14
Q

Patients WITH inflammation associated to liver fat accumulation are diagnosed with what?

A

Nonalcoholic Steatohepatitis (NASH)

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15
Q

Patients WITHOUT inflammation associated to liver fat accumulation are diagnosed with what?

A

Nonalcoholic Fatty Liver Disease (NAFLD)

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16
Q

What are inherited Liver diseases that present as Chronic Hepatitis?

A

Hemochromatosis
A1-Antitrypsin deficiency
Wilson Disease

17
Q

What is responsible for Intrahepatic Cholestasis?

A

Functional or Mechanical Problems

18
Q

What is responsible for Extrahepatic Cholestasis?

A

Physical Obstruction of the bile ducts

19
Q

What is an autoimmune disorder targeting Intrahepatic Ducts found in middle aged women?

A

Primary Biliary Cirrhosis (PBC)

20
Q

What is an inflammatory disease affecting Extrahepatic ducts found in men?

A

Primary Sclerosing Cholangitis (PSC)

21
Q

What are the most common symptoms of Primary Sclerosing Cholangitis?

A

Pruritus (Itching)
Intermittent Abdominal Pain
Fever

22
Q

What is the most important Primary liver tumor?

A

Hepatocellular Carcinoma (HCC)

Liver (5 decks)

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