Rodriguez Lecture 1 Anti-virals Flashcards
How do most antivirals attack viruses?
Inhibits nucleic acid or protein synthesis
The 5 types of Herpes virus that cause eye infection
HSV-1, HSV-2, Varicella Zoster, Cytomegalovirus (CMV), Epstein Barr Virus
What form is Vidarabine?
Ointment 3%, only available in compounding pharmacies
How does Vidarabine attack virus?
Intervene with DNA synthesis. Has a purine nucleoside analog that resembles deoxydenosine.
What viruses do Vidarabine attack?
HSV-1 and 2, Varicella Zoster Virus.
What is the pharmacology of trifluridine?
It is a viroptic solution of 1%. It inhibits DNA synthesis. Thymidine analog. Originally used in cancer pts.
What is the clinical use of Trifluridine?
DOC HSV keratitis. 1gtt every 2 hours while awake. 6-7 days. Wait 5 mins after trifluridine to use lubricating drops so it is not diluted.
What are the side effects of Trifluridine?
Burning and stinging sensation, corneal punctuate keratpathy, severe dry eye (Keratoconjunctivitis sicca) and an icreased IOPs. Most prevalent in elderly.
How is virus treated?
With topical and oral medications.
Who is Varicella Zoster mostly seen in
More in elderly
Who is CMV mostly seen in?
more in imunno compromised pts. (HIV)
What is the pharmacology of Gancyclovir (Zirgan)
Will replace trifluridine. 0.15% Gel. Inhibits DNA synthesis.
What does Zirgan treat?
Herpes Keratitis. I gtt in eye 5 times a day. “Off label” more common in pediatric population.
what nerve does Herpes effect?
usually affects trigeminal nerve.
800 vs. 200 vs. 400Acyclovir
800 - varicella Zoster, 200-400 Herpes Simplex
