Roberta Brinton Alzheimers Talk

Question 1

4 major risk factors

Answer 1

Age
Female
ApoE 4 gene
Maternal hx of dz

Question 2

% of patient that have Alzheimer’s that are women

Answer 2

67%

Question 3

DNA is passed from mother to child these 2 ways

Answer 3

1. X chromosome
2. Mitochondria

Question 4

Percentage women with cognitive symptoms in menopause

Answer 4

56%

Question 5

Glucose metabolism decreases in menopause

Answer 5

.

Question 6

Obesity and Alzheimer’s

Answer 6

Increased risk prior to age 65 but gain is protective after 65

Question 7

How do men and women’s metabolisms differ?

Answer 7

Women: lipid focused
Men: amino acid focused

Question 8

Brain changes with symptomatic perimenopause

Answer 8

Decreased white mater and beta amyloid deposites

Question 9

Allo

Answer 9

Neural stem cells (allopregnanolone) - currently in clinical trials

Question 10

Metabolic dysfunction and diabetes increase Alzheimer’s risk

Question 11

Statins decrease risk of Alzheimer’s in women

Question 12

Adaption in brain to reduced glucose metabolism

Answer 12

Ketone metabolism, first from peripheral fat and then white mater

Question 13

Possible ways to reduce Alzheimer’s risk

Answer 13

Transdermal estrogen
Adequate sleep and exercise
Oil based vit D, fish oil, calcium, and chocolate(?) at night

Question 14

Phytoestrogen sources

Answer 14

Soybeans & alfalfa
(Healthy woman soy supplement)