Clinical Notes Flashcards

1
Q

Pregnancy diabetes goals

A

63-140mg/dL
TIR 75-85%

A1C <6.5% prior to conception

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2
Q

New diabetes med C/I in pregnancy

A

SGLT2

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3
Q

C Telopeptide normal and target ranged

A

100-600normal
>300 think about restarting therapy for osteoporosis

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4
Q

When should you check 24hr Uribe calcium in osteoporosis?

A

Severe disease or not responding to therapy

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5
Q

How many units of insulin for black coffee?

A

1U

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6
Q

TURN OFF REVERSE CORRECTION

A

(Unless pump in manual mode)

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7
Q

Vit D target

A

30-60

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8
Q

How much but D to prescribe?

A

50,000 qd for 1wk if very low (teens)

Otherwise 50,000 weekly for 3mo and recheck

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9
Q

Frequency of A1C and CGM discrepancy

A

About 1/3 ppl

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10
Q

Pharmacodynamics of Byetta

A

Glp1
Very short 6hr 1/2 life
Consider using like bolus

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11
Q

Age of dx of T1DM

A

50% <21
25% 21-39
25% 40 & up

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12
Q

Percentage of patients on GLP1 w/o side effects

A

80%

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13
Q

Adjusting basal when starting pump

A

Usually 75% of prior dose

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14
Q

Calculate insulin in carb ration

A

500/TDD

*how many grams of carb are covered by 1 U insulin

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15
Q

Calculate insulin correction factor

Aka insulin sensitivity factor

A

1800/TDD

*how many points 1U of insulin will lower blood glucose

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16
Q

When changing a patient from MDI to a pump you should adjust insulin by:

A

Decreasing TDD by 25%

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17
Q

Ultra fast acting insulins

A

Fiasp and lyumjev

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18
Q

Diabetes distress survey

A

PAID score

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19
Q

Which insurance requires that pumps and CGMs be sent to a DME pharmacy?

A

Medicare

(Byram, CCS Medical, Wellstart, ADS)

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20
Q

SGLT2 inhibitors only work if your blood sugar is …

A

> 180

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21
Q

Typical TSH normal range

A

0.3-3.0

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22
Q

Pregnancy TSH target

A

<2.5

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23
Q

Adjusting levothyroxine dose in pregnancy

A

Increase by 20%

Extra tab 2 days a week

(Resume regular dose immediately after delivery)

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24
Q

EPI

A

Exocrine pancreatic insufficiency

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25
Symptoms of EPI
Increased foul smelling gas and loose stool
26
Risk factors for EPI
Pancreatitis, pancreatic díctala carcinoma, cystic fibrosis, long-standing diabetes, prior intestinal surgery
27
Testing for EPI
Fecal elastase <100mcg suggestive
28
GLP1 agonist meds have been around since…
2005
29
Metformin has been around in Europe since
1955
30
Consider ananolic meds for osteoporosis when T score is..
<-3
31
How do steroids impact TSH?
Could decrease TSH
32
How could low TSH impact liver enzymes?
Could increase AST & ALT due to myopathy
33
Neuropathy supplements
Alpha lipoid acid and B1 (thiamin)
34
LDL treatment for statin intolerant patients
PCSK9 therapy Bempedoic acid 180mg daily Zetia Prescription fish oil (lovaza or omtryg 2caps twice daily)
35
Adjusting insulin for gestational diabetes post partum
Often insulin not needed 2 days post delivery
36
Insulin adjustment when going from long acting to ultra long acting
Decrease by 10%
37
Testosterone treatment lab monitor
1/2 time between shots check cbc, hepatic panel, and testosterone free and total q3-6mo PSA also check annually -Medicare requires cpt for testosterone monitoring to cover
38
Switching from 1-2mg of ozempic to mounjaro
10mg
39
LDL goals in diabetics
<70 But <55 if heart disease or nephropathy
40
MEN III
Medullary thyroid carcinoma Medulla of adrenal (pheo) Mucosal neuroma
41
MEN II
Medullary thyroid carcinoma Medulla of adrenal (pheo) Parathyroid hyperplasia
42
MEN I
Pituitary tumors Parathyroid hyperplasia Pancreatic tumors (insulinoma and gastrinoma)
43
Metformin MOA
1. Decrease liver glucose output 2. Increase peripheral insulin sensitivity
44
How high does blood sugar have to be for SGLT2 inhibitors to work?
180
45
Weight stigma language
AVOID: diet, exercise, limit, restrict, ideal weight, extra large USE: eating style/preferences, movement, physical activity, choose/experience, healthy weight, appropriate size
46
Pregnancy TSH goal
<2.5
47
Pregnancy levothyroxine adjustment
Increase by 20% or 2 pills per week Resume normal dose immediately following delivery
48
Antihypertensive preferred in adrenal insufficiency
CCB
49
Which part of BP is more predictive of CV risk?
<50yr diastolic >50yr systolic
50
Severity of hypoglycemia
Mild if <70 Moderate if < 55 Severe if altered mental status
51
How does acute illness impact DM2?
Increased insulin resistance that can last up to 2wk
52
Hypothyroidism in pregnancy
1. Increase dose by 20% or 2pills weekly 2.Monitor T4 and TSH ever 1-2mo. Keep TSH <2.5 3. Resume regular dose immediately after delivery 4. Check for thyroiditis 6wk pp
53
Possible medication for post bariatric hypoglycemia
Acarbose
54
DME companies for insulin pumps
Byrum ADS Performance medical Wellstart
55
Most common cause of ectopic cushings
50% small cell lung cancer
56
Treatment if hypercalcemia if malignancy
Hydration IV BP or prolia Calcimimetic
57
Hormones released by adrenal medulla
Epinephrine Norepinephrine Dopamine
58
Hormones released by adrenal cortex zona glomerulosa
Mineralicorticoids: Aldosterone
59
Hormones released by adrenal cortex zona fasiciculata
Glucocorticoids : cortisol, cortisone, and corticosterone
60
Hormones released by adrenal cortex zona reticularis
Androgens, estrogen, aldosterone, and DHEAS
61
Trans women biochemical treatment goals
Estradiol in 100s Testosterone in low range/female range LH & FSH suppressed
62
Satiety hormone released by pancrease
Amylin (Some t1dm are deficient)
63
Supplements for neuropathy
B1 (benfotiamine/thiamine) Alpha lipoic acid
64
Pseudohypoparathyroidism can be caused by this electrolyte abnormality
Hypomagnesemia
65
Dx labs with hypoparathyroidism
Low calcium, PTH, urinary calcium, and vit D High or normal phosphate
66
Treatment for symptomatic hypocalcemia
IV calcium gluconate in DSW
67
Tx for hypoparathyroidism
Calcium citrate or carbonate Calcitriol Vit D Thiazide if hypercalciuric Phosphate binder possibly New PTH analog if refreactory
68
Hypoparathyroidism in pregnancy
Monitor q 3-4wk Adjustment up and down often needed
69
8 most common complications of hypoparathyroidism
Cataracts Infection Nephrolithuasis/calcinosis Renal insufficiency Arrhythmia (QT prolongation) Ischemic heart dz Depression Seizures
70
Palopectaryparotide
PTH analong - prodrug conjugated to carrier molecule
71
Calcium supplementation while on PPI
Can not use carbonate Use citrate instead
72
Tx hyperphosphatemia
Take calcium supplement with meal Low phosphate diet Consider phosphate binder
73
Preferred HTN tx with adrenal insufficiency
CCB
74
Affect of Crestor on LDL with weekly administration
20% per DrCW
75
Lab that needs to be monitored with benpodoic acid tx
Uric acid
76
TSH goal with pregnancy and pregnancy planning
<2.5 prior to conception 0.2-2.5 1st trimester 0.3-3.5 2nd and 3rd trimester
77
This electrolyte deficiency can cause pseudohypoparathyroidism
Magnesium
78
Supplements for neuropathy
B1 - thiamine/benfotiamine (300-600mg) Alpha lipoic acid (600-1200mg)
79
Labs with hypoparathyroidism
LOW: PTH, serum and urine Calcium, vit d HIGH to norm: phosphate
80
This lab predicts Cushings dz recurrence best
ACTH
81
Cushings Dz treatment
Transphenoidal tumor resection Radiation Medication Bilateral adrenalectomy
82
Crushings disease medications
Antitumor: pasireotide or cabergoline Glucocorticoid receptor blocker: mifepristone Steroidogenesis inhibitor: ketoconazole, lovelkeyonkonazoke, metryapone, osilodrostat
83
Thyroglobulin monitoring
Every 6mi for 2yr then annually
84
Central diabetes insipidus tx
DDAVP
85
Nephrogenic diabetes insipidus tx
Thiazide or acetazolamide as needed for hypernatremia