Risk Factors and Vessel Injury Questions Flashcards
What are the non modifiable factors in CVD?
Gender
Age
Family History
What are the modifiable factors in CVD?
Diet Smoking Stress and anger Overweight HBP High Cholesterol Diabetes Lack of activity and exercise Age
How to act on reducing modifiable factors
Diet
Medications
Excercise
What causes vessel damage that leads to CAD?
Risk factors and PCI
Under Optimal Flow, how does functional endothelial cells protect against atherosclerosis and thrombosis?
Through the production of Nitric Oxide and other factors
Stretching of vessel wall results in?
Increased production of Nitric Oxide.
What does stretching of vessel also known as
Cyclic strain
Heart Pumping pressure to the vessels is also known as
Pulsatile strain
Steady Lamina Flow + sheer stress results in…
Results in a number of protective signals
Lowing of lamina flow and sheer stress will result in lesser protective signaling. T/F?
True
When vascular injury occurs, the process of repair and healing can result in either normal endothelial functioning or dysfunction. T/F?
True
_______________ which is released by endothelium is the most potent natural inhibitor of platelet aggregation.
Prostacyclin
_______________describes the artery’s ability to expand outward as plaque builds up in the arterial wall, thus keeping the lumen patent.
Accomodative remodelling
List the benefits of a normally functioning endothelium that is exposed to hemodynamic forces, such as pusatility, cyclic strain and physiologic levels of sheer stress.
Nitric Oxide production
Barrier of LDL migrating to vessel wall
Anti growth
List the following are negative consequences of a dysfunctioning endothelium that is not exposed to hymodynamic forces such as pusatility, cyclic strain and either high or low levels of sheer stress.
Thrombosis Inflammation Disease progression Vasoconstriction Loss of barrier to Low Density Lipoprotein (LDL) migration
