Rischer Chapter 6: Fluid and electrolyte content Flashcards
Basic Metabolic Panel (BMP)/Chemistries ALWAYS RELEVANT (5)
- sodium
- potassium
- glucose
- Creatinine
- Glomerular filtration rate (GFR)
Potassium
- 5-5.0 mEq/L
- essential to normal cardiac electrical conduction
- tends to deplete more quickly with loop diuretic usage than magnesium
Sodium
135-145 mEq/L
- foundational fluid balance electrolyte
- fluid volume deficit due to dehydration –> sodium elevated
- fluid volume excess –> sodium low
Glucose
fasting: 70-110 mg/dL
- required fuel for metabolism
- elevated levels post-op can increase risk of infection/sepsis
Creatinine
and
Glomerular filtration rate (GFR)
creatinine: 0.6-1.2 mg/dL
GFR: >60 mL/minute
-gold standard for kidney function and adequacy of renal perfusion
-elevated creatinine can indicate damage to fragile capillary membrane screen of the glomerulus, allowing protein and glucose to pass through
CBC ALWAYS RELEVANT (4)
- WBC
- Neutrophils
- Hemoglobin
- Platelet count
WBC
4500-11,000/mm^3
-correlated with the presence of inflammation or infections
Neutrophils
50-70%
- correlated with the presence of inflammation or infections
- most common leukocyte (first responder to any bacterial infection within several hours)
Hemoglobin
- male: 13.5-17.5 g/dL
- female: 12.0 -16.0 g/dL
- determines anemia or acute/chronic blood loss
Platelet count
150-450 x 103/ microliter
- relevant when there is concern for anemia or blood loss or patient is on heparin
- watch for thrombocytopenia in heparin patients
Cardiac ALWAYS RELEVANT (3)
- troponin
- CPK-MB
- BNP (B-natriuretic peptide)
troponin
<0.4 ng/mL
- ordered to rule out MI
- can take up to 6 hours after attack to elevate
- labs always ordered every 6-8 hours x3
- can be slightly elevated and positive in heart failure and unstable angina
- patients with renal disease (usually CKD III-IV) are unable to clear troponin by kidneys and will have baseline low positive (track the trending for theses patients)
CPK-MB
<5%
- specific iso-enzyme for cardiac muscle
- confirms presence of MI
- used to confirm troponin based MI diagnosis
BNP
<100 ng/L
- neurohormone secreted by myocytes in the ventricles
- compensates for overstressed ventricles by being a vasodilator and diuretic
- elevated in heart failure
Coagulation ALWAYS RELEVANT (1)
- PT/INR
PT/INR
- 9 - 1.1 nmol/L
- therapeutic: 2-3 nmol/L
- measures time for firm fibrin clot to form and measures clotting cascade
- dependent on vitamin K synthesis from the liver
- elevated in liver disease (unless on warfarin/Coumadin to achieve therapeutic goal of INR 2-3)
- extremely important for patients on warfarin!
Misc Chemistries ALWAYS RELEVANT (2)
- Magnesium
2. Lactate
Magnesium
- 6 -2.0 mEq/L
- essential to normal cardiac electrical conduction
- too high or low –> can predispose to rhythm changes
Lactate
- 5-2.2 mmol/L
- trend with any shock state (especially sepsis)
- elevated level –> higher likelihood of death
Basic Metabolic Panel (BMP)/Chemistries
SITUATIONAL (5)
- chloride
- CO2
- Anion Gap
- Calcium
- BUN
Chloride
95-105 mEq/L
-Relevant if NG suction or frequent vomiting is present
CO2
22-28 mEq/L
-actually reflecting the amount of bicarbonate (HCO3-)
Anion Gap (AG)
7-16 mEq/L
- difference between primary measured cations (Na+ and K+) and primary measured anions (Cl- and HCO3-) in serum
- relevant to acid base concerns typically seen in renal failure
Calcium
- 4-10.2 mg/dL
- relevant with renal failure and ETOH abuse
- Hypocalcemia can occur in the case of low albumin
- Hypercalcemia can be seen with cancer
BUN
7-25 mg/dl
- relevant to renal failure (important to trend with creatinine) but can be elevated for other reasons
- elevated with dehydration