Rheumatology/ortho Flashcards
What pathogens are most common in neonatal septic arthritis? (3)
- GBS
- Staph aureus
- Gram neg bacilli (E coli, klebsiella, salmonella, pseudomonas)
What pathogens are most common in septic arthritis in infants? (4)
- Staph aureus
- Streptococcus spp
- Haemophilus influenzae
- Kingella kingae
What pathogens are most common in septic arthritis in children?
- Staph aureus
- Strep pneumoniae
- Strep pyogenes
- Kingella kingae
What pathogens are most common in adolescents with septic arthritis? (4)
- Staph aureus
- Strep pneumoniae
- Strep pyogenes
- Neiserria gonorrhoeae
What pathogen is the most common cause of septic arthritis/osteomyelitis overall?
Staph aureus
What criteria do you need for a diagnosis of rheumatic fever?
- 2 major
- 1 major, 2 minor
PLUS evidence of preceding GAS
What are the major criteria for rheumatic heart disease (+any changes if high risk)? (5)
- Evidence carditis (high risk: can be subclinical valvulitis seen on echo)
- Polyarthritis (HR: can be polyarthralgia or monoarthritis)
- Subcutaneous nodules
- Chorea
- Erythema marginatum
What are the minor criteria for acute rheumatic fever?
- Prolonged PR interval
- Polyarthralgia or monoarthritis (this is a major for HR. Minor for HR is monoarthralgia)
- CRP >30, ESR >30
- Fever
What is the nature of arthritis in ARF? (number joints, how it changes, response to analgesia)
- Polyarthritis
- Migratory (can leave a joint after 1 hour even) and additive
- Responds to NSAIDs
What valve is most affected in rheumatic heart disease?
Mitral valve (50-60%) (MR + aortic is 20%)
What cytokine does infliximab target?
TNF-alpha
What cytokine does adalimumab target?
TNF alpha
What cytokine does rituximab target?
CD-20
What cytokine does anakinra target?
IL-1
What cytokine does tocilizumab target?
IL-6
