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WolfPacc Rheumatology/MSK > Rheumatology/MSK > Flashcards

Rheumatology/MSK Flashcards

1
Q

What is Primary Biliary Cirrhosis?

A

Seen in females, pruritus, xanthomas, anti-mitochondrial antibody

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2
Q

What is Primary Sclerosing Cholangitis?

A

p-ANCA antibody, bile duct inflammation, onion skinning, IBD

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3
Q

What is Type I Autoimmune Hepatitis?

A

Seen in young women, anti-smooth muscle Ab

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4
Q

What is Type II Autoimmune Hepatitis?

A

Seen in kids, Anti-LKM Ab

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5
Q

What is Bullous Pemphigold?

A

Anti-Hemidesmosome Ab, subepithelial skin bullae

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6
Q

What is Celiac Sprue?

A

Anti-Gliaden Ab can’t eat wheat / bread products = Steatorrhea, Associated with Dermatitis Herpetiformis

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7
Q

What antibody is associated with CREST Syndrome?

A

Anti-Centromere Ab

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8
Q

What is Dermatitis Herpetiformis?

A

Vesicles on anterior thigh, Anti-BMZ Ab, Anti-Endomysial Ab

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9
Q

What is Dermatomyositis?

A

Anti-Jo-1 Ab Myositis with a rash, Associated with occult malignancy

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10
Q

What is DM Type 1?

A

Polyuria, Polydipsia, weight loss, Anti-Islet cell Ab, Anti-GAD Ab, post infection, DKA

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11
Q

What is Drug Induced Lupus?

A

Anti-Histone Ab “HIPPPE” drugs cause this. H – Hydralazine, I – INH, P – Phenytoin, P – Procainamide, P – Penicillamine, E - Ethosuximide

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12
Q

What is Gastritis Type A?

A

Anti-Parietal cell, an Atrophic Gastritis Adenocarcinoma

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13
Q

What is Goodpasture’s?

A

Anti- GBM Ab, attacks the lung and kidney, can progress to RPGN and death

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14
Q

What is Grave’s Disease?

A

Anti-TSHr Ab, Hyperthyroid, Exophthalmos, Pretibial Myxedema

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15
Q

What is Hashimoto’s?

A

Anti-Microsomal Ab / anti-TPO Hypothyroid

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16
Q

What is ITP (Immune Thrombocytopenic Purpura)?

A

Anti-Platelet Ab Anti - GP2b3a Ab Thrombocytopenia

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17
Q

What is MCTD (Mixed Connective Tissue Disease)?

A

Anti-RNP Ab

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18
Q

What is Mononucleosis?

A

Heterophile Ab positive, teenager with sore throat, Lymphadenopathy, Splenomegaly, kissing disease

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19
Q

What is MPGN Type II?

A

Anti-C3 convertase Ab = C3 nephritic factor

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20
Q

What is Paroxysmal Hemolysis?

A

Donath Landsteiner Ab, (they bleed when they are cold)

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21
Q

What is Pemphigus Vulgaris?

A

Anti-Desmosome Ab (skin sloughs off when touched), starts in oral mucosa

22
Q

What is Pernicious Anemia?

A

Anti-IF Ab, vitamin B12 deficiency = Megaloblastic Anemia

23
Q

What is Polyarteritis Nodosa?

A

p-ANCA Ab, attacks the gut kidneys and nervous system, associated with Hep B infection, there is no pulmonary environment

24
Q

What is Post-Strep GN?

A

ASO Ab, Nephritic with complement deposition, after 3 weeks post infection

25
Q

What is Rheumatoid Arthritis?

A

Rheumatoid factor present pain and swelling is worse in the morning, anti-citrullinated peptide protein antibodies

26
Q

What is Scleroderma?

A

Anti-Scl70 Ab, (Anti-TopoI) fibrosis tight skin, masked faces

27
Q

What is Sjogrens?

A

Anti-SSA Ab, dry eyes, dry mouth, arthritis

28
Q

What is SLE?

A

Anti-ds DNA / Sm / Cardiolipin Ab, Malar Rash, photosensitivity, oral ulcers, rheumatoid factor positive, VDRL test but not infected, FTA-ABS to confirm

29
Q

What is SLE Cerebritis?

A

Anti-Neuronal Ab, Anti-Ribosomal Ab

30
Q

What is Vitiligo?

A

Anti-Melanocyte Ab, white patches on skin

31
Q

What is Warm Hemolysis?

A

Anti-Rh Ab, bleeds at body temperature

32
Q

What is Wegner’s?

A

c-ANCA Ab, attacks ENT, lungs, and kidney

33
Q

What is HSP?

A

IgA Disease 2 or 3 days post common cold or GI infection, leads to Berger’s

34
Q

What is Berger’s?

A

IgA Disease 2 weeks post vaccination, serum sickness

35
Q

What is Alport’s?

A

IgA Disease 2 weeks after diarrhea, HSP, and Polio

36
Q

Where is CK-MB found?

A

Heart

37
Q

Where is CK-MM found?

A

Muscle

38
Q

Where is CK-BB found?

A

Brain

39
Q

Why should you wait 30 minutes after a meal before swimming?

A

All blood is shunted to the GI for digestion, digestion depletes ATP, stores No ATP = No muscle movement

40
Q

How does a Neurogenic Muscle Disease present?

A

Distal weakness and fasciculation’s

41
Q

How does a Myopathic Muscle Disease present?

A

Proximal weakness and pain

42
Q

What is a Light Chain Composed of?

A

Actin

43
Q

What is a Heavy Chain Composed of?

A

Myosin

44
Q

What Band of the Sarcomere does not change length?

A

The A Band

45
Q

Where are the T-Tubules located?

A

Cardiac Muscle: At the Z line, Skeletal Muscle: At the A-I Junction

46
Q

What is Duchenne’s Muscular Dystrophy?

A

Caused by a Dystrophin Frameshift Defective Dystrophin, patients will have a Gower sign and calf Pseudohypertrophy

47
Q

What is Becker’s Muscular Dystrophy?

A

Dystrophin Missense, milder form of DMD, symptoms present after 5 years of age.

48
Q

What is seen with Myotonic Dystrophy?

A

Bird’s Beak Face, can’t let go when they shake hands

49
Q

What is Myasthenic Syndrome?

A

Patients will tell you they get stronger as the day goes by, stronger with EMG, Is associated with small cell CA - Lambert-Eaton Syndrome

50
Q

What is Myasthenia Gravis?

A

Anti-ACH postsynaptic Ab, patients between approximately 20-30 years old get weaker as the day goes by (dysarthria, Ptosis and dysphagia), periotic exacerbations get stronger with Edrophonium, weaker on EMG, must rule out Thyoma

51
Q

What is Multiple Sclerosis?

A

Due to production of Anti-Myelin antibody, Seen more common in 20-40 year old women, complain of vision disturbances, spasticity (UMN), decreased sensation, symptoms wax and wane - each MS attack gets worse

WolfPacc Rheumatology/MSK (3 decks)

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