Rheumatology - Johns

Question 1

What x-ray findings do you see in osteoarthritis?

Answer 1

X-ray Findings:

Sclerosis
-New bone formation in the subchondral trabeculae

Osteophytes
-Formation of new bone at the joint margins

Loss of cartilage

Question 2

General Clinical Features of Osteoarthritis?

Answer 2

Age over 50
stiffness
Crepitus
bony enlargement
can have increased synovial fluid but NO inflammation

Question 3

ESR in osteoarthritis would show?

Answer 3

ESR is NOT elevated

Question 4

QUick rundown of rheumatoid arthritis features?

Answer 4

Usually symmetric
Inflammatory arthritis
Chronic, progressive, disabling
Systemic problems like fatigue, fever, weight loss

Question 5

What are articular manifestations?

Answer 5

Subcutaneous nodules
Pericarditis
Pulmonary nodules/ Interstitial fibrosis
Inflammatory Eye Disease
Episcleritis / Scleritis
Vasculitis

Question 6

What serological test would test positive in a patient with Rheum arthritis?

Answer 6

Positive RF

Positive CCP Antibody

Question 7

What lab test would be indicative of rheumatoid arthritis?

Answer 7

Elevated CRP and ESR!

Question 8

What kind of therapy do you use for rheumatoid arthritis?

Answer 8

You have to recognize adn treat early before joint is destroyed.

DMARDs and biological DMARDs

Question 9

What is juvenile idiopathic arthritis?

Answer 9

Chronic synovial inflammation 
Unknown cause
Prevalence: between 57 and 220/100,000 children
Age < 16
girls > boys
No diagnostic laboratory tests
Different subtypes:
Systemic onset
Polyarticular onset 
Pauciarticular onset