Arachidonic Acid - Trachte

Question 1

Which enzyme is most likely to release arachidonic acid from membrane:

Cyclooxygenase
Lipoxygenase
Phospholipase A2
Phospholipase C
PGE synthase
PGI synthase
Thromboxane synthetase

Answer 1

Phospholipase A2

Question 2

Which of the following is most likely to cause inflammation:

Arachidonic Acid
Epoxides
Isoprostanes
Leukotrienes
PGE2
Prostacyclin
Thromboxane A2

Answer 2

PGE2

Question 3

COX2 inhibitors primarily block arachidonic acid metabolism in endothelial cells to cause myocardial infarction. The synthesis of which of the following products is inhibited most:

Arachidonic Acid
Epoxanes
Isoprostanes
Leukotrienes
PGE
Prostacyclin
Thromboxane

Answer 3

Prostacyclin

Question 4

Which of the following is most likely to cause myocardial infarction:

Arachidonic acid
Epoxanes
Leukotrienes
PGD
PGE
Prostacyclin
Thromboxane A2

Answer 4

Thromboxane A2

Question 5

Celecoxib is a cox2 inhibitor and has less potential to cause what complication?

Answer 5

gastric ulcers

because it doesn’t block COX1, which is important in the stomach

Question 6

What drug is an irreversible blocker of cycooxygenase?

Answer 6

Acetylsalycilic acid

Question 7

Why have COX2 inhibitors like Rofecoxib and Valdecoxib been withdrawn from the market?

Answer 7

These drugs increase the risk of cardiovascular thrombosis!