Rheumatology - guess The Disease Flashcards

1
Q

Felty syndrome

A

RA + neutropaenia + splenomegaly

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2
Q

Chrondrocalcinosis

A

Pseudogout

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3
Q

% of people with psoriasis who develop PA

A

20%

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4
Q

4 main SE of methotrexate

A

Pneumonitis
Lung fibrosis
Liver fibrosis
Myelosuppression

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5
Q

Pre-check before giving azathioprine

A

TPMT levels. 1 in 200 have a deficiency that can lead to pancytopaenia

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6
Q

Contraception with methotrexate

A

During and for 3 months after treatment

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7
Q

Major drug interaction with methotrexate

A

Trimethoprim (And co-trimoxazole).

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8
Q

What do you co prescribe with methotrexate

A

Folate

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9
Q

Frequency of giving methotrexate

A

Weekly

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10
Q

Guidelines for treatment of new onset RA

A

Methotrexate
+ 1 other DMARD (e.g. Sulphasalazine)
+ short term prednisolone

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11
Q

HLA association of RA

A

HLA DR4/DR1

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12
Q

HLA association with PA

A

60-70% association with HLAB27

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13
Q

SE of colchicine

A

Diarrhoea

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14
Q

Allopurinol drug interaction

A

Azathioprine + allopurinol –> bone marrow suppression

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15
Q

HLA association of ank spond

A

90% HLAB27

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16
Q

6As of ank spond

A
Aortic regurgitate
Anterior uveitis
AV block
Achilles tendinitis 
Apical lung fibrosis
Amyloidosis
17
Q

Guidelines for bone protection with vit D, calcium and alendronate

A

If >65 or previous fragility fracture –> treat

If <65 with no fragility fracture –> Do DEXA, if T score

18
Q

1st line treatment for OA

A

Paracetamol + topical NSAIDs (hand or knee)

19
Q

Complement levels in SLE

A

C3 and C4 low

20
Q

Main 2 drugs causes drug induced lupus

A

Procainamide

Isoniazid

21
Q

Pathophysiology of amauroses fugax in giant cell arteritis

A

Anterior ischaemic optics neuropathy

22
Q

Special features of dermatomyositis

A

Muscle –> progressive proximal weakness, no pain. Arthralgia.
Skin –> gottron papule, shawl sign, heliotrope rash, nail fold erythema

23
Q

Associated disease with dermatomyositis

A

Malignancy

24
Q

JIA eye symptoms

A

Anterior uveitis (like the seronegatives, and unlike RA which is episcleritis and scleritis)

25
Q

Treatment of Raynaud

A

1st line - CCBs like nifedipine

2nd line - iloprost IV prostacyclin

26
Q

Marfans mutation and inheritance

A

AD fibrillin gene

27
Q

Symptoms of pagets diseas of the bone

A

Only 1 in 20% are symptomatic:
Bone pain
Tibia bowing
Frontal bossing/thickened calvarium

28
Q

Blood tests in pagets

A

Raised ALP and nothing else

29
Q

Prevalence of pagets

A

5% (only 1 in 20 are symptomatic)

30
Q

Treatment of pagets

A

Bisphosphonate

31
Q

Behcets triad + other symptoms

A

Oral ulcer
Genital ulcer
Anterior uveitis

Others:
Thrombophlebitis
Arthritis
Aseptic meningitis

32
Q

Pethargy test

A

Pustule formation after small puncture

Behcets

33
Q

Symptoms of osteomalacia

A

Bone pain
Muscle tenderness
Proximal myopathy

34
Q

Bloods with osteomalacia

A

ALP raised

Low calcium, vit D and phosphate

35
Q

X-ray for osteomalacia

A

Losers zones