Rheumatology - guess The Disease Flashcards
Felty syndrome
RA + neutropaenia + splenomegaly
Chrondrocalcinosis
Pseudogout
% of people with psoriasis who develop PA
20%
4 main SE of methotrexate
Pneumonitis
Lung fibrosis
Liver fibrosis
Myelosuppression
Pre-check before giving azathioprine
TPMT levels. 1 in 200 have a deficiency that can lead to pancytopaenia
Contraception with methotrexate
During and for 3 months after treatment
Major drug interaction with methotrexate
Trimethoprim (And co-trimoxazole).
What do you co prescribe with methotrexate
Folate
Frequency of giving methotrexate
Weekly
Guidelines for treatment of new onset RA
Methotrexate
+ 1 other DMARD (e.g. Sulphasalazine)
+ short term prednisolone
HLA association of RA
HLA DR4/DR1
HLA association with PA
60-70% association with HLAB27
SE of colchicine
Diarrhoea
Allopurinol drug interaction
Azathioprine + allopurinol –> bone marrow suppression
HLA association of ank spond
90% HLAB27