Rheumatology - guess The Disease Flashcards
Felty syndrome
RA + neutropaenia + splenomegaly
Chrondrocalcinosis
Pseudogout
% of people with psoriasis who develop PA
20%
4 main SE of methotrexate
Pneumonitis
Lung fibrosis
Liver fibrosis
Myelosuppression
Pre-check before giving azathioprine
TPMT levels. 1 in 200 have a deficiency that can lead to pancytopaenia
Contraception with methotrexate
During and for 3 months after treatment
Major drug interaction with methotrexate
Trimethoprim (And co-trimoxazole).
What do you co prescribe with methotrexate
Folate
Frequency of giving methotrexate
Weekly
Guidelines for treatment of new onset RA
Methotrexate
+ 1 other DMARD (e.g. Sulphasalazine)
+ short term prednisolone
HLA association of RA
HLA DR4/DR1
HLA association with PA
60-70% association with HLAB27
SE of colchicine
Diarrhoea
Allopurinol drug interaction
Azathioprine + allopurinol –> bone marrow suppression
HLA association of ank spond
90% HLAB27
6As of ank spond
Aortic regurgitate Anterior uveitis AV block Achilles tendinitis Apical lung fibrosis Amyloidosis
Guidelines for bone protection with vit D, calcium and alendronate
If >65 or previous fragility fracture –> treat
If <65 with no fragility fracture –> Do DEXA, if T score
1st line treatment for OA
Paracetamol + topical NSAIDs (hand or knee)
Complement levels in SLE
C3 and C4 low
Main 2 drugs causes drug induced lupus
Procainamide
Isoniazid
Pathophysiology of amauroses fugax in giant cell arteritis
Anterior ischaemic optics neuropathy
Special features of dermatomyositis
Muscle –> progressive proximal weakness, no pain. Arthralgia.
Skin –> gottron papule, shawl sign, heliotrope rash, nail fold erythema
Associated disease with dermatomyositis
Malignancy
JIA eye symptoms
Anterior uveitis (like the seronegatives, and unlike RA which is episcleritis and scleritis)
Treatment of Raynaud
1st line - CCBs like nifedipine
2nd line - iloprost IV prostacyclin
Marfans mutation and inheritance
AD fibrillin gene
Symptoms of pagets diseas of the bone
Only 1 in 20% are symptomatic:
Bone pain
Tibia bowing
Frontal bossing/thickened calvarium
Blood tests in pagets
Raised ALP and nothing else
Prevalence of pagets
5% (only 1 in 20 are symptomatic)
Treatment of pagets
Bisphosphonate
Behcets triad + other symptoms
Oral ulcer
Genital ulcer
Anterior uveitis
Others:
Thrombophlebitis
Arthritis
Aseptic meningitis
Pethargy test
Pustule formation after small puncture
Behcets
Symptoms of osteomalacia
Bone pain
Muscle tenderness
Proximal myopathy
Bloods with osteomalacia
ALP raised
Low calcium, vit D and phosphate
X-ray for osteomalacia
Losers zones
