Rheumatology - antibodies Flashcards
1
Q
Rheumatoid arthritis
A
99% anti-CCP
70% RF
Some anti-Ro and anti-La (ANA) as well
2
Q
SLE
A
99% ANA
20% RF
Anti-dsDNA = >99% specific, 70% sensitive
Anti-Smith = >99.9% specific, 30% sensitive
3
Q
Systemic sclerosis - diffuse type
A
Anti-topiopsomerase (Scl-70)
4
Q
Systemic sclerosis - limited
A
Anti-centromere
5
Q
Dermatomyositis
A
ANA
Anti-Jo is most specific, but not as sensitive
Auntie-Jo has dermatomyositis
6
Q
Juvenile idiopathic arthritis
A
10% RF
7
Q
Churg-Strauss
A
pANCA
8
Q
Wegners granulomatosis
A
cANCA
9
Q
Sjogrens
A
RF 100%
ANA 70%
Anti-Ro 70%
Anti-La 30%
10
Q
Antiphospholipid syndrome
A
Anti-cardiolipin
11
Q
Drug-induced lupus
A
Anti-histone
12
Q
RF in normal population
A
10%
