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Year 2 > Rheumatology Drugs > Flashcards

Rheumatology Drugs Flashcards

1
Q

Methotrexate mechanism?

A

Folate antagonist

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2
Q

Methotrexate side effects?

A

Myelosuppression
Liver cirrhosis
Pneumonitis (urgent respiratory help)

Teratogenic (stop 3 months before conception - both male and female)

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3
Q

Sulfasalazine side effects?

A

Oligospermia (decreased sperm count)
Rash
Mouth ulcers
Heinz body anaemia

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4
Q

Hydroxychloroquine drug class?

A

Anti-malarial

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5
Q

Hydroxychloroquine side effects?

A 
Irreversible retinopathy (annual ophthalmology review)
Corneal deposits
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6
Q

Leflunomide mechanism?

A

Inhibits Dihydroorotate dehydrogenase

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7
Q

Leflunomide side effects?

A

Interstitial lung disease
Hepatotoxicity (liver impairment)
Hypertension
Oral ulcers

TERATOGENIC - not given in pregnancy, to female or male partner

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8
Q

IM Gold side effects?

A

Proteinuria

Peripheral neuropathy

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9
Q

Mechanism of penicillamine?

A

Unknown in RA

Chealating agent in Wilson’s Disease

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10
Q

Side effects of penicillamine?

A

Rash - pseudoxanthoma elasticum
Aggravation of myasthenia syndrome
Proteinuria

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11
Q

Azathioprine class?

A

Mercaptopurine derivative

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12
Q

Azathioprine side effects?

A

Marrow suppression (myelosuppression)
Hepatotoxicity
Acute pancreatitis
Teratogenic

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13
Q

Mechanism of ciclosporin?

A

Blocks cytotoxic T cell activation (CD8+)

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14
Q

Ciclosporin side effects?

A

Immune suppression - therefore infection risk
Nephrotoxicity
Hypertension
Hepatotoxicity

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15
Q

Prednisolone mechanism?

A

Binds glucocorticoid receptor (alpha/beta)

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16
Q

Prednisolone effects?

A

Salt/water retention
Increased gluconeogenesis
Increased hepatic glycogen deposition
Increased protein breakdown

17
Q

Prednisolone side effects?

A 
Osteoporosis
Impaired glucose tolerance (potentially DM)
Hypertension
Cataracts
Glaucoma
Cushingoid features (central obesity)
Adrenal suppression
AVN of femoral head
Immunosuppression
18
Q

Subcutaneous anti-TNF drugs?

A

Etanercept
Adalimumab
Certdizumab
Golimumab

19
Q

IV anti-TNF drugs?

A

Infliximab

20
Q

Anti-TNF therapy side effects?

A

All - reactivation of TB
Increased skin cancer potentially?
Etanercept - demyelination

21
Q

Contraindications for anti-TNF therapy?

A

Heart failure
Pulmonary fibrosis
Latent TB

22
Q

What causes oligospermia?

A

Sulfasalazine

23
Q

What causes proteinuria?

A

Gold

Penicillamine

24
Q

What causes reactivation of TB?

A

All anti-TNF

In particular: Infliximab and Etanercept

25
Q

What causes pulmonary fibrosis?

A

Methotrexate

Leflunomide

26
Q

What causes retinopathy?

A

Hydroxychloroquine

27
Q

What causes cataracts?

A

Prednisolone

28
Q

What causes exacerbation of Myasthenia Gravis?

A

Penicillamine

29
Q

What causes demyelination?

A

Etanercept

30
Q

What drugs are teratogenic?

A

Methotrexate
Leflunomide
Azathioprine

31
Q

What anti-TNF drug is given IV?

A

Infliximab

32
Q

2 eye problems caused by prednisone?

A

Cataracts

Glaucoma

33
Q

2 eye problems caused by Hydroxychloroquine?

A

Retinopathy

Corneal deposits

34
Q

Side effects of Rituximab?

A

Infusion reactions common

Year 2 (19 decks)

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