Rheumatology Approach to arthritis Flashcards

1
Q

Types of Rheumatic disease?

A
Noninflammatory
Collagen Vascular Disease
Inflammatory
Muscle Diseases
Infectious Diseases
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2
Q

Highest disease causing disability?

A

arthritis

more than cardiac, pulmonary, blind/deaf, hypertension, diabetes, stroke

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3
Q

Signs of inflammation?

A

erythema, swell, pain, heat

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4
Q

Most common cause of arthritis in adults?

A

osteoarthritis

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5
Q

Osteoarthritis prevalence?

A
under 30 1%
40-50 10%
50-60 50%
65 75%
75 100%
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6
Q

Risk factors Osteoarthritis?

A
obestiy
joint dysplasia
trauma
occupation
high bone density
family history
low vit D and C intake
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7
Q

Primary Osteoarthritis?

A

Localized (trauma, slipped capitol femoral epiphysis, occupation)

Generalized (congenital, idiopathic)

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8
Q

Secondary Osteoarthritis?

A

Dysplastic (Chondrodysplasia, Epiphyseal dysplasia, developmental)
Post Traumatic (acute, repetitive, surgical)
Endocrine and metabolic
Post-inflammatory
Structural

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9
Q

Clinical features of Osteoarthritis?

A
History of joint pain
not systemic
no extra-articular symptoms
usually insidious
increases with age
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10
Q

Radiography for Osteoarthritis?

A

plain xray is the most useful
other types of imaging are rarely needed
-asymmetric narrowing, sclerosis, subchondral cysts, osteophytes (bone spur)

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11
Q

Natural history Osteoarthritis?

A

slowly progressive
hypertrophic rxn on xrays
cartilage loss
loss of function

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12
Q

Treatment goals Osteoarthritis?

A

control symptoms
maintain function
limit disability
avoid drug toxicity (disease does not kill, pharm does)

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13
Q

Treatment guidelines?

A

No opiod analgesics in hand, avoid in knee

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14
Q

Why avoid oral NSAIDs?

A

GI toxicity, ulcers, perforations

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15
Q

Capsaicin use?

A

for hand OA, not knee OA

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16
Q

Treat OA hand?

A
evaluation
training in joint conservation
train in heat/cold
topical oral/NSAIDs
Capsaicin
Tramodol
No opiod analgesics
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17
Q

Treat OA knee?

A

weight loss
strength exercise
manual therapy in conjunction with supervised exercise
use insoles
thermal agents
walking aides
acetaminophen, topical NSAIDs, oral NSAID, injection
avoid opiods
no nsaids with chronic renal stage IV, V
do not use chondroitin, topical capsaicin, glucosamine

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18
Q

Treat OA hip?

A
self manage
weight loss
CV exercise
thermal agents, manual therapy in conjunction with supervised exercise
actaminophen
oral NSAIDs
Tramadol
intraarticular injection
no recommendations (topical NSAIDs, Duloxetine, Opioid, Hyaluronate)
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19
Q

Diffuse Idiopathic Skeletal Hyperostosis?

A

DISH
bone hypertrophy at the ligament and tendon insertions
usually aymptomatic
associated with Type II diabetes
most common in the thoracic spine on the right
following calcifications

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20
Q

Chondromalacia patellae?

A
affects mainly young women
localized OA at the patellae
may be a precursor to OA of the knee
in early stages Xray are normal
diagnosed based on Physical exam
21
Q

Rheumatoid arthritis?

A

progressive, systemic, inflammatory disorder
unknown etiology
charaterized by:
symmetric synovitis, joint erosions, multisystem extraarticular manifestations

22
Q

RA and DIP?

A

generally it spares the DIP

23
Q

Common signs of RA?

A

ulnar deviation, sublux of MCP

synovitis, spongy feel, effusion bag of water, generally spare DIP

24
Q

Importance of early diagnosis?

A

progressive, benign
structural damage/disability occurs within the first 2-3 years of disease
slower progression of disease is linked to early development

25
RA characteristics?
``` may be abrupt or insidious peak incidence women in their 50s joint pain less related to use prolonged stiffness with inactivity not limited to the MSK system ```
26
DIfferential Diagnosis?
thyroid disease, hemachromatosis, paraneoplastic, reactive arthritis, polyarticular gout
27
Criteria for RA?
``` morning stiffness >1 hr arthritis of > 3 joint areas arthritis of finger of joints symmetric joint swelling (must be present for at least 6 wks) serum RF Rheumatic nodules typical radiographic changes ```
28
Is laboratory data diagnostic?
no, need to diagnose based on patient
29
Lab data?
RF, Anti-CCP antibody, ESR, CBC, c reactive protein, phase reactants
30
Radiographic data of RA?
obtain baseline films ask for evidence of specific parameters not diagnostic by itself c1-c2 affected because its similar to MCP joints
31
c1-c2?
similar to MCP, erode the dens, hyperextended neck
32
RA of the skin?
rheumatoid nodules vasculitis still diseases drugs
33
RA of HEENT?
iritis, uveitits, conjunctivitis, scelritis, episceritis, sicca, hearing loss
34
Sicca?
dry eyes, dry mouth | can cause ulcers
35
RA of Pulmonary?
``` intersitial lung disease cricoarytenoid pleura drug rhuematoid nodules ```
36
Kaplans disease?
coalminer, smokers | nodules in lung that look like metastasis
37
RA of GI?
mesenteric vasculitis ulcer disease with and without treatment pernicious anemia
38
RA of renal?
intersitial renal diseas proteinuria drug effects mesangial GN
39
RA of Neuro?
C1-C2 subluxation entrapment neuropathy peripheral neuropathy vasculitis
40
RA of bone?
osteoporosis avascular necrosis osteomyelitis
41
RA of hematologic?
Anemia, leukopenia, thrombocytopenia, lymphadeopathy, lymphoma
42
RA of syndromes?
Sjorgens, Caplans, Feltys, Amyloid A, Vasculitis, Immunodeficiency, Depression
43
Swan neck?
flex MCP, extend PIP, flex DIP
44
Treatment of RA?
early treatment 90% of radiographic erosions occur within the first 2 years of synovitis onset early intervention with DMARDs may prevent long term disability and premature mortality
45
Objectives of treat RA
preserve function diminish symptoms delay or prevent progession
46
NSAIDs?
control symptoms, decrease swelling, decrease stiffness, provide symptom control, do not alter the course of the disease
47
NSAIDs side effects?
GI, renal, hepatic, cardiac
48
Steroids?
intra-articular, systemic, pulse | short time, no renal evidence to change disease course
49
Methotrexate?
DMARD