Rheumatology Antibodies

Question 1

Antibodies found in RA

Answer 1

Rheumatoid factor

Anti-CCP (ACPA)

Question 2

which antibodies are negative in seronegative spondyloarthropathies?

Answer 2

RF

Anti-CCP (ACPA).

Question 3

What blood test is associated with seronegative spondyloarthropathies

Answer 3

HLA-B27

Question 4

Which of the seronegative sponds has the highest correlation with HLA-B27

Answer 4

ankylosing spondylitis

Question 5

Which autoantibodies are positive in SLE?

Answer 5

ANA (not specific)
Anti-dsDNA - 50%
Anti-RO / LA

Question 6

What complement levels are decreased in SLE?

Answer 6

C3

C4

Question 7

What antibodies are positive in antiphospholipid syndrome?

Answer 7

Anti-β2-glycoprotein-1

anti-cardiolipin antibodies

Question 8

What antibody is positive in limited systemic scleroderma?

Answer 8

ANA - not specific to systemic scleroderma

Anticentromere antibodies

Question 9

Which antibodies are positive in sjogren’s

Answer 9

RF+
ANA
Anti-RO
Anti-La

Lip and salivary gland biopsy - focal infiltration of lymphocytes and plasma cells

Question 10

What antibodies are associated with adult polymyositis?

Answer 10

Anti-Jo-1 antibodies and other t-RNA synthetases are associated

Question 11

What antibodies are associated with dermatomyositis?

Answer 11

MSA - myositis specific antibodies

Question 12

What conditions present with positive cANCA?

Answer 12

granulomatosis with polyangiitis (WEGENER’s)

Question 13

What conditions present with positive pANCA?

Answer 13

Churg-Strauss syndrome

Question 14

What is the antibody test for antiphospholipid syndrome?

Answer 14

lupus anticoagulant (LA) and anti-cardiolipin antibodies (aCL)

Question 15

What antibodies are associated with drug induced lupus?

Answer 15

antihistone

Question 16

What antibodies are associated with diffuse systemic sclerosis?

Answer 16

Anti-Scl-70

RNA polymerase