Pharmacological therapy Flashcards

1
Q

Which drug should not be co-prescribed with methotrexate?

A

Trimethoprim / co-trimoxazole - increases risk of marrow aplasia

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2
Q

How should folic acid be taken with methotrexate?

A

24 hours after

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3
Q

What is the treatment for methotrexate toxicity?

A

Folinic acid

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4
Q

How long should a patient stop taking methotrexate for before trying to conceive?

A

6 months

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5
Q

What is the treatment for Paget’s disease of the bone?

A

Bisphosphonates

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6
Q

What is the treatment for Raynaud’s?

A

Nifedipine (CCB)

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7
Q

What is the most prominent side effect of bisphosphonates?

A

Oesophageal problems

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8
Q

What is the drug treatment for osteomalacia?

A

Vitamin D supplementation

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9
Q

What is the management of patients who suffer bad GI side effects from alendronate?

A

Change to risedronate

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10
Q

What drugs can cause drug induced lupus?

A

hydralazine (most common)

isoniazid, penicillamine, procainamide, phenytoin

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