Rheumatology Flashcards
What is the mechanism of action of Corticosteroids?
- Prevent interleukin 1 and IL-6 production by macrophages
- Inhibits all stages of T-cell activation
When are Corticosteroids used?
- Malignancy
- Psoriasis/Psoriatic arthritis
- Crohn’s disease
- Vasculitis
- Maintenance therapy in vasculitis
- Steroid sparing agent in asthma
What is the mechanism of action of Methotrexate?
- Competitively and reversibly inhibits dihydrofolate reductase
- Inhibits purine and thymidine synthesis so therefore inhibits DNA, RNA and proteins
- Cytotoxic in the S-phase of the cell and has a greater toxic effect on rapidly dividing cells.
When is methotrexate used?
- Cancer
- Non-malignant disease such a R.A psoriasis. Mechanism is not via anti-folate action
Well tolerated and 50% of patients continue drug for more than 5 years. Improved QOL. Retardation of joint damage
What are the side effects of Methotrexate?
- Mucositis (response to folic acid supplementation)
- Marrow suppression (respond to folic acid supplementation)
- Hepatitis
- Cirrhosis
- Pneumonitis
- Infection Risk
- High tetragenic and abortifacient
What are the pharmacokinetics of Methotrexate?
- Oral bioavailability is 33% and intramuscular is 76%
- Administered PO, IM or S/C
- Weekly dosing.
- 50% protein bound so NSAIDs can displace
What is the mechanism of action of Sulfasalazine?
- Inhibition of T cell proliferation
- T cell apoptosis
- Inhibition of IL-2 production
- Reduced chemotaxis of neutrophil
- Reduced degranulation of neutrophils
What are the uses of Sulfasalazine?
- Relief of pain and stiffness in RA and to finght infection
- Used for Inflammatory arthritis
- Effective in IBD (activity in intestine)
What are the side effects of Sulfasalazine?
Mainly due to sulfapyridine moiety
- Myelosuppression
- Hepatitis
- Rash
Other
- Nausea
- Abdominal pain/vomiting
What are the features of Sulfasalazie in practice?
- Effective and favorable toxicity
- Very few interactions
- Long term blood monitoring not always needed
- No carcinogenic potential and safe in pregnancy
What is the mechanism of action of Azathioprine?
Cleaved to 6-mercatopurine
Anti-metabolite decreases DNA and RNA synthesis
What are the use of Azathioprine?
- SLE & Vasculitis - as maintenance
- Rheumatoid arthritis
- Inflammatory bowel disease
- Atopic dermatitis
- Bullous skin disease
What are the side effects of Azathioprine?
- Bone marrow suppression (monitor FBC)
- Increased risk of malignancy (Esp transplanted patients)
- Increased risk of infection
- Hepatitis (monitor LFT)
What are the features of the metabolism of Azathioprine?
- Metabolised by thiopurine methyltransferase
- TPMT gene is highly polymorphic
- Individuals vary markedly in TPMT activity
What can result from low/absent TPMT level?
- Risk of myelosuppression
- Test TPMT activity before prescribing