Rheumatology Flashcards

1
Q

Disc Prolapse

A

Age 40 male
Severe Lower Back Pain (LBP)
Spread into his buttock and Rt thigh
Relieved if lie down

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2
Q

Spinal stenosis due to osteophytes

A

Age 74 male
Backpain for last 2 yrs, lately worse
Refers to his buttock
Worse when he walks for a distance
Improve by sitting going down hill

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3
Q

Malignancy

A

Age 54 female
LBP for last 3/12, progressive worse
difficulty urinating and numbness in Rt leg
Absent knee reflex on the Rt

Semi-acute duration
Progressively worse
Some neurology

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4
Q

Do not miss/exclude

A

Inflammatory arthritis (Spondyloarthropathies)
Spinal Infection
Neoplasms
Fractures
Referred visceral pain

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5
Q

Red flags for lowerback pain

A

1)Neurological deficit
2)Trauma
3)Prev. surgery
4)Prolonged use of corticosteroids
5)Malignancy
6)Immunosuppression
7)Osteoporosis
8)Age onset < 20years
9)Inflammatory nature of pain
10)Unexplained fever/weight-loss

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6
Q

Mechanical lower back pain (causes)

A

-Nonspecific back pain (Muscle, tendon, ligament strain)
-Degenerative Disease (Spondylosis): Discs, Facet Joints
-Herniated Disc
-Spinal Stenosis
-Spondylolysis and Spondylolisthesis
-Fractures (Non- vs Osteoporotic)
-Severe kyphosis / scoliosis

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7
Q

MLBP Tx

A
  • physical therapy to strengthen the back muscle
    -some analgesia
    -surgical intervention
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8
Q

Spondolysis

A

arthritis of the spine. Seen radiographically as disc space narrowing, osteophyte formation and arthritic changes of the facet joint.

  • localized lumbar pain, but can refer downwards.
  • Worse with standing or sitting, as well as with physical activity
  • C-spine OA present with lateral neck pain, which do not refer below shoulders, worsen by lateral flexion or extension.
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9
Q

Herniated Disc

A

Acute onset
L4-L5/L5-S1 = 98%
Sharp, shooting, shock-like pain (often into legs)
Management often conservative initially
Typical Hx = pain in the center of the lower back with minimal radiation(if present locates to the buttocks or thighs), Deep dull ache pain, Improves = with standing, lying flat, reduce by extension. Worsen = with sitting, driving, lumbar flexion, bending, twisting, Valsalva maneuver, and coughing

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10
Q

Spinal Stenosis

A

Narrowing of the central spinal canal by bone or soft tissue elements, usually bony hypertrophic changes in the facet joints and by thickening of the ligamentum flavum
>60 yrs
Pain on extension (walking ,standing, going downhill, positional changes)
Relief (flexion) = Improved by rest, sitting, and lumbar flexion.
gluteal and lower extremity pain
fatigue that may or may not occur in conjunction with lower back pain

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11
Q

Spondylolysis & Spondylolisthesis

A

Fracture in pars interarticularis where the vertebral body and the posterior elements are joined. (L5)

Spondylolisthesis refers to the slipping forward of one vertebra on the next

When the defect in the pars interarticularis is not associated with a forward displacement, the term spondylolysis applies. LBP symptom, exacerbated by motion, lumber extension & twisting. Relieved extended rest. Progress to radicular pain into L5 distribution

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12
Q

Spondylolysis & Spondylolisthesis treatment

A

Bracing and rest are the cornerstones
Pain control and avoiding sports
Physical therapy should not be started until after an adequate rest period and once pain with daily activities has subsided: goals = Decrease extension stress of lumbar spine, strengthen elements that promote an anti-lordotic posture
slippage <50% + patient symptomatic = non-operative therapy (Stretching & strengthening exercises, anti-lodic brace, activity modification.)
Spina fusion (pain persists)

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13
Q

Cauda Equina Syndrome

A

Surgical emergency!

Typical Features:
Bladder / bowel dysfunction(urine retention + overflow)
Bilateral leg weakness/ numbness
Saddle sensory loss

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14
Q

Yellow flags - Chronicity

A

Beliefs that pain and activity is harmful
Emotional issues (depression / anxiety)
Work issues (dissatisfaction)
Compensation issues
History of LBP

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15
Q

Inflammatory Back Pain

A

pain/stiffness = >60min morning, improves during day
activity = improve symptoms
duration = chronic
age of onset = <40 years
Radio = sacroiliitis, spinal ankylosis, syndeamophytes

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16
Q

Inflammatory Back Pain (Features)

A

Plantar periostitis
Enthesitis
IBD
Uveitis
Psoriasis

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17
Q

ASAS/EULAR Recommendations for the Management of AS

A

Education, exercise, physical therapy, rehabilitation, patient associations, self help groups
NSAIDs
Axial /Peripheral disease, Analgesics
Surgery
Sulfasalazine
Local corticosteroids
TNF blockers

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18
Q

Golfer’s elbow

A

Medial Epichondilitis
inflamed, but the tendon insertions of the flexors of the forearm, which is why when he uses those muscles to flex his wrist, it aggravates the pain
part of Soft Tissue Rheumatisms

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19
Q

Soft Tissue Rheumatisms

A

pathology is in the ligaments, tendons and bursae surrounding a joint and not the joint itself

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20
Q

Clinical pattern recognition (Articular)

A

Deep diffuse pain
Active and passive painful
Joint swelling
Crepitation
Joint instability
Locking of the joint
Deformity

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21
Q

Clinical pattern recognition (Non- Articular)

A

Localized pain
Only Active painful
Point or local tenderness
Crepitation rare
physical findings are remote from joint capsule

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22
Q

Examples of soft tisue rheumatisms

A

Tennis elbow (lateral side)
De Quervain’s tendonitis
Rotator Cuff Syndrome
Tronchanteric bursitis
Anserine bursitis
Achilles tendinitis

23
Q

Rheumatoid arthritis

A

Inflammatory in nature – worse in morning with morning stiffness (prominent, >1hour) eg. Lasting more 6 weeks
Poli-arthritis – multiple joints
Inflamed synovium
Symmetrical
Wrist / MCPs / PIPs is typical pattern of involvement
Swelling present
Sometimes = Redness, Warmth, fever, drenching night sweats, unintentional weight-loss

24
Q

Osteo-arthritis

A

67yr old lady – typical age >60 years
Painful when knitting – mechanical type on pain
Bony deformities = Heberden’s nodes
Distal joints (DIPs) – typical pattern
Cartilage loss
(Morning) Stiffness not prolonged (10-15 minutes) <30min
Asymmetrical
No swelling, redness, fever, drenching night sweats, unintentional weight-loss
Warmth = very rarely
worse = evening

25
Q

55yr man, severely painful Rt knee, 2 days, hypertensive, TB, loosing weight and experiencing some fever

A

Gout
Right age with Hpt - ? Possible metabolic syndrome which is associated
Acute onset
On TB treatment – PZA can trigger attack

Versus

Septic arthritis
Only 1 joint
Acute onset
Fever

26
Q

Pain on Rt and Lt, 2 or more joints affected , Relieved by voltaren but pain persists

A

asymmetrical arthritis affecting a few (oligo-arthritis) affecting the weight-bearing joints of the lower limbs, is very typical of a Reactive arthritis (ReA)

27
Q

Mono-arthritis (1 joint):

A

Septic
Gout
Pseudogout
Avascular necrosis (AVN)
Hemarthrosis
Trauma
Chronic infections (Mycobacterium/Fungal/Cryptococcus/Nocardia/Lyme’s disease
Prev chronic RA

28
Q

Oligo-arthritis (2-4):

A

Reactive arthritis
Psoriatic
Sarcoidosis
IBD

29
Q

Poli-arthritis (>4):

A

RA
OA
Gout
CPPD
SLE & Other CTD’s
Viral

30
Q

Symmetrical:

A

RA
OA
CTD’s

31
Q

Asymmetrical:

A

2-4 joints
Reactive arthritis (ReA)
Psoriatic (PsA)

32
Q

Axial involvement:

A

Ankylosing Spondylitis
ReA
PsA
Arthritis assoc with IBD

33
Q

Episodic course:

A

Gout
Pseudogout
Rheumatic fever
Autoinflammatory syndromes (Familial Mediterranean fever etc)
Reactive arthritis
Palindromic rheumatism

34
Q

Extra-articular disease (Mucocutaneous manifestations)

A

Photosensitivity (SLE, Dermatomyositis)
Raynaud’s phenomenon (Scleroderma, Mixed Connective Tissue disease)
Mouth ulcers (SLE, Reactive arthritis(ReA))
Subcutaneous nodules (RA, Rheumatic fever, Gout)
Erythema nodosum (ReA, Arthritis assoc with IBD)
Nail dystrophy (Psoriatic arthritis(PsA))
Cutaneous vasculitis (Any CTD)

35
Q

Extra-articular disease (Ocular disease)

A

Keratoconjunctivitis sicca (Sjogren’s)
Conjunctivitis (ReA)
Scleritis (RA)
Uveitis (Ankylosing spondylitis)
Retinal vasculitis (Bechet’s, any CTD)

36
Q

EAD (Renal)

A

Acute renal failure (SLE, All vasculitides)
Glomerulonephritis (SLE, Wegener’s)
Renal calculi (Gout)

37
Q

EAD (cardiopulmonary dx)

A

Pleuritis (SLE)
Pericarditis (SLE, Rheumatic fever)
Interstitial lung disease (RA, Scleroderma, SLE, Ank Spond)
Nodules – other than sub-cutaneous (RA, Gout)
Pulmonary hypertension (Scleroderma)
Valvular heart disease (Rheumatic fever, SLE, Ank Spond)
Myocarditis (SLE, Vasculitides

38
Q

EAD (Neuro dx)

A

Mononeuritis multiplex (Vasculitides, SLE)
Stroke (Vasculitides, SLE)

39
Q

Joint exam

A

Look: Swelling, Posture, Deformity, Redness
Feel: Warmth, Bogginess, Tenderness
Move: Limited range of movement (ROM), Crepitus, Stability
Active to Passive movement
Manoeuvres like Pain with Resisted movement

40
Q

Septic arthritis

A

Rapid onset, Typically Mono-articular, Inflammatory arthritis, Joints most commonly affected: Knee (50%), Hip (common in children), Ankle, Shoulder
Aetiology: Young sexually active adults (Neisseria gono.) , Elderly (Staph A, Strept. pneum., grame - bacilli)
Risk fx: Prosthetic joints, Skin infection, Joint surgery, Previous damaged joints (RA), Elderly (>80 years old), Diabetes mellitus, Intravenous drug use, Atypical joints affected

41
Q

Polyarticular Infective causes

A

-Gonnococcal arthritis (Neisseria gonorrhoeae)
-Bacterial endocarditis – septic emboli
-Viral disease = Hepatitis B virus, Parvovirus B19, HIV, Rubella virus
-Arthropod-borne viruses (Tick bite fever)
-Rheumatic fever
-Poncet’s disease (Reactive immunological process against TB, not actually AFB’s in joints)

42
Q

Gout (Initially)

A

Acute onset
First metatarsophalangeal joint most commonly (>50% of cases)
Intermittent
Asymmetrical joint involvement
Fever

43
Q

Gout (Later)

A

Tophous gout
Poli-arthritis
Chronic, losses it’s episodic nature, but can still have attacks
Commonly affect the elbows and hands
Can mimic RA

44
Q

Gout

A

Risk fx: Obesity, Diabetes mellitus, Hyperlipidaemia, Hypertension, Alcohol use, Thiazide diuretics, Renal insufficiency, Myeloproliferative diseases
Investigations: FBC: ↑ WCC, ESR/CRP (during acute attack) ↑ serum urate, Urate crystals in synovial fluid and/or tophi
X-ray= Asymmetric soft tissue swelling
‘Punched out’ bay-like erosions – not necessarily assoc with joint

45
Q

polyarthritis

A

Aetiology: acute (<6w) =viral (lyme dx)
Chronic(>6w) = <60 years: RA, SLE, PA
>60 years: (Gout/CPPD), OA

46
Q

Osteoarthritis (Sx)

A

Most common form of arthritis
Prevalence increase directly with age (Uncommon < 40 years)
Pain worsens with use
Morning stiffness < 30min
Slow progressive deformity – bony
(Heberden / Bouchar’s)
No systemic manifestation

47
Q

Joint distribution (OA)

A

Joints commonly involved:
-Larger weight-baring joints: Knee, Hip
-Hands: DIP (Heberden’s nodes), PIP (Bouchard’s nodes), First carpometacarpal joint
-Cervical and lumbar spine

Joints spared: Wrist, MCP joints, Elbow, Shoulders, Ankle

48
Q

OA (more info)

A

X-ray: Joint space narrowing, Subchondral sclerosis, Osteophytes, Subchondral cysts
Lab: Normal FBC, Normal ESR or slight increase in ESR (mild ↑ in erosive OA), -ve RF, -ve ANA

49
Q

RA (signs and sx)

A

Inflammatory Polyarthritis, symmetrical, affects small and large joints, Affects all ethnic groups
40-60 years
+ Rheumatoid factor = supports dx but clinical dx (Don’t need RF sero -)
Morning stiffness
Spares: DIP joints
MCP subluxation with ulnar deviation!!!!
Z- deformity

50
Q

RA (lab, x- ray, classification)

A

Lab: FBC: Anaemia, thrombocytosis , ↑ ESR/CRP +ve RF (60-70%) , aCCP (60-70%)
X-ray: Soft tissue swelling, Juxta-articular osteopenia, Uniform joint space narrowing, Marginal erosions
Classification: ≥6/10 = RA

51
Q

SLE (signs & sx)

A

Involve many organs
20-40 yrs
F>M
Early morning stiffness
Symmetrical polyarthritis
Joints: PIP, MP, wrist, elbows, shoulders, knees, ankles and MTPJ
Malar/discoid rash

52
Q

SLE (Lab,X-ray, Classification)

A

Lab: FBC: Anaemia, ↓ WCC/lymphopaenia, ↑ ESR, normal CRP, +ve ANA (99%)
X-ray: Soft tissue swelling, Joint space narrowing, No erosions.
Classification: Clinical vs Immunologic

53
Q

SLE clinical

A

Acute cutaneous lupus
Chronic cutaneous lupus
Oral ulcers
Non-scarring alopecia
Synovitis > 2 joints
Serositis
Renal
Neurologic
Hemolytic anemia
Leucopenia/Lymphopenia
Thrombocytopenia

54
Q

SLE Immunological

A

ANA
Anti-dsDNA
Anti-Sm
aPL antibodies
Low complement
Direct Coomb’s test