Rheumatoid Arthritis and Methotrexate Flashcards

1
Q

Symptoms of Rheumatoid Arthritis

A
  • inflammation joints
  • pain / stiffness
  • fatigue
  • tenderness
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2
Q

What can exacerbate Rheumatoid Arthritis

A

bring sedentary

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3
Q

What is the 1st Line treatment of Rheumatoid Arthritis

A

DMAR

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4
Q

What is the 2nd Line treatment of Rheumatoid Arthritis

A

Dual DMARD

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5
Q

What is the 3rd Line treatment of Rheumatoid Arthritis

A

Monoclonal Antibodies (Adalimumab)

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6
Q

Examples of DMARDs

A
  • Methotrexate
  • Sulfasalazine
  • Hydroxychloroquine
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7
Q

What should you do if rapid treatment of Rheumatoid Arthritis is needed

A

bridge DMARD therapy with corticosteroids

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8
Q

What can be offered for pain until DMARDs kick in

A

NSAIDs

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9
Q

Which NSAID should you not use with Methotrexate

A

Ibuprofen

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10
Q

What should the prescription and label of methotrexate both show

A

dose and frequency

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11
Q

If methotrexate is prescribed with folic acid what should the administration be

A

do not taken folic acid on the same day as you take methotrexate

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12
Q

What should patients report

A
  • liver
  • respiratory
  • blood

effects

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13
Q

What is used to treat Methotrexate toxicity

A

Folinic Acid

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14
Q

Methotrexate and Contraception

A
  • Must use during treatment
  • 6 months after

men and women

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15
Q

Methotrexate Side effects

A
  • blood disorders
  • liver toxicity
  • respiratory toxicity
  • gastrointestinal toxicity
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16
Q

What symptoms of Gastrointestinal toxicity of Methotrexate

A
  • stomatitis (inflammation of mucus membranes in mouth)
  • Diarrhoea
17
Q

Methotrexate Interactions

A
  • nephrotoxic drugs
  • Anti-folates
  • Hepatotoxic Drugs
  • Omeprazole/esomeporazole
18
Q

Examples of Anti-folate drugs

A
  • trimethoprim
  • Phenytoin