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Rheumatology > Rheumatoid arthritis > Flashcards

Rheumatoid arthritis Flashcards

1
Q

Aetiology?

A

Genetic
Smoking
Trauma
Infection

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2
Q

Pathology?

A

Immune response against synovium, denuding of articular cartilage leading to joint destruction and instability and subluxation

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3
Q

Clinical features?

A 
Symmetrical synovitis
Pain
Morning stiffness
MCPs and PIPs affected, DIPs are NOT
Rheumatoid nodules
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4
Q

Which joints are spared in RA?

A

DIPs

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5
Q

Investigations?

A

Rheumatoid factor
Anti-CCP
General inflammatory markers (CRP, PV, ESR)
X-ray - show nothing at onset, periarticular erosion in advanced disease

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6
Q

Three varieties of treatment?

A

Short term symptom relief
DMARDs
Biologics

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7
Q

Short term symptom relief

A

Analgesia
NSAIDs
Intra-articular/oral steroids

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8
Q

Examples of DMARDs?

A

Methotrexate - 1st line
Sulphasalazine
Hydrochloroquine

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9
Q

Examples of biologics?

A

Infliximab
Rituximab
Abatacept

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10
Q

What kind of drug in infliximab?

A

Anti-TNF

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11
Q

What does rituximab do?

A

Interferes with B cell function

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12
Q

What does abatacept do?

A

Interferes with T cell function

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13
Q

Downsides of DMARDs and biologics?

A

Immunosuppressive

- especially at risk of TB with biologics

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14
Q

Most common ocular extra-articular manifestation?

A

Keratoconjunctivitis sicca

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Rheumatology (8 decks)

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