Rheumatic Heart Disease Flashcards
Definition
A sequela of pharyngeal streptococcal infection caused by Group A, Beta-hemalytic S. pyogenes pharyngitis
An autoimmune disease caused by cross-reactions between Strep antigens and the antigens on joint and heart tissue
Rheumatic fever is a systemic immune process may or may not lead to RHD
RHD is a valvular abnormality secondary to rheumatic fever most often manifesting as mitral stenosis
Symptoms
Presents 1-2 weeks after a Group A Strep infection (usually pharyngitis)
with any combination of a variety of symptoms that together lead to diagnosis
Jones Criteria
Used to diagnose RHD
Evidence of a preceding group A streptococcal infection plus two major critertia or one major and two minor criteria
Major Criteria
Migratory polyarthritis
Carditis (myocarditis, pericarditis)
Erythema marginatum
Subcutaneous nodules
Chorea
Minor Criteria
Fever
Antecedent strep infection
Arthralgias
Elevated ESR
Prolonged PR internal
Evaluation
Labs
Positive rapid antigen testing
Positive ASO and/or DNAase B
Elevated ESR
Evaluation
Imaging
Doppler echocardiography may demonstrate valvular insufficiency or ventricular dysfunction
Heart catheterization only indicated in cases of chronic disease to evaluate mitral and aortic valves and potentially balloon stenosed valves
EKG
Sinus tachycardia in most cases may demonstrate sinus bradycardia in patients with decreased vagal tone can show varying degrees of heart block depending on severity of case
Differential
RA, SLE, endocarditis, osteomyelitis, Lyme’s Disease, Sickle cell disease, any variety of
isolated valvular disorders
Treatment
Penicillin V indicated for treatment of acute rheumatic fever
Clindamycin indicated for chronic carriers of GABHS
Salicylates for fever
Prognosis, Prevention, and Complications
Prognosis is good if treated acutely
Prophylaxis against further streptococcal infection:
No evidence of carditis: 5 years or until age 21 (whichever is longer)
Evidence of carditis without valvular abnormalities: 10 years or until age 21 (whichever is longer)
Evidence of carditis and valvular abnormalities: 10 years or until age 40 (whichever is longer)
Complications depend on severity of disease can range from none to complete heart block