Digoxin Flashcards

1
Q

Clinical use

A

CHF → ↑ contractility

Atrial fibrillation → ↓ conduction at AV node via ↑ in parasympathetic tone

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2
Q

MOA

A

Direct inhibition of Na+/K+ ATPase
↓ Na+ gradient results in indirect inhibition of
Na+/Ca2+ exchanger/antiport

↑ [Ca2+]i → positive inotropy

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3
Q

Toxicity

A

Blurry yellow vision
Cholinergic; nausea, vomiting, diarrhea
Fife-threatening arrhythmias; ↑ PR, ↓ QT, T-wave inversion
May ↑ increase K+ serum levels
Renal insufficiency ↑ digoxin toxicity
Hypokalemia ↑ digoxin toxicity; without K+, digoxin can bind to Na+/K+ ATPase; digoxin competes for excretion and competes for tissue-binding sites

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4
Q

Antidote KLAM

A

Slowly normalize K+
Lidocaine
Digoxin Antibodies (anti-dig Fab fragments)
Mg2+

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