Digoxin Flashcards
1
Q
Clinical use
A
CHF → ↑ contractility
Atrial fibrillation → ↓ conduction at AV node via ↑ in parasympathetic tone
2
Q
MOA
A
Direct inhibition of Na+/K+ ATPase
↓ Na+ gradient results in indirect inhibition of
Na+/Ca2+ exchanger/antiport
↑ [Ca2+]i → positive inotropy
3
Q
Toxicity
A
Blurry yellow vision
Cholinergic; nausea, vomiting, diarrhea
Fife-threatening arrhythmias; ↑ PR, ↓ QT, T-wave inversion
May ↑ increase K+ serum levels
Renal insufficiency ↑ digoxin toxicity
Hypokalemia ↑ digoxin toxicity; without K+, digoxin can bind to Na+/K+ ATPase; digoxin competes for excretion and competes for tissue-binding sites
4
Q
Antidote KLAM
A
Slowly normalize K+
Lidocaine
Digoxin Antibodies (anti-dig Fab fragments)
Mg2+