Rheumatic disease 1 Flashcards
What is meant by degenerative
occurs in age
- osteoarthritis
what is meant by articular
affects joints
what are the 2 categories of articular disease
inflammatory or degenerative
give examples of inflammatory disease
RA, SLE
give examples of degenerative disease
osteoarthritis
-hand, large joints, spine
what are the characteristics of articular inflammatory disease
- often symmetrical involvement
- small joints always affected, sometimes large joints
- EMS> 30 mins, pain with activity
- soft tissue swelling
describe how the ACR/EULAR criteria is used to diagnose RA
point system divided in sections
1. joint distribution
2. serology
3. symptom duration
4. acute phase reactants
- score above 5 indicates RA
Describe the onset of RA
Usually a slow, insidious onset over weeks to months
- about 15% of individuals have rapid onset
- about 8% have acute symptoms that develop over days
give examples of RA non joint features
- nodules
- sicca
- dry eyes
- others (uncommon)- inflammation in blood vessels
what is the causation of RA
- genetic and environmental factors (smoking)
- complex and poorly understood
- HLA determines severity and involves different gene systems
- trigger could be injury/virus or infection
what could RA lead to if left untreated
- disability
- damage
- deformity
- death
outline the treatment and prognosis of RA
- NSAIDS
- steroids
- conventional synthetic disease modifying antirheumatic drugs (csDMARDS)
- targeted synthetic disease modifying antirheumatic drugs (tsDMARDS)
- biologic disease modifying antirheumatic drugs (bDMARDS)
describe the surgical intervention methods that can be used for RA
- removal of inflamed synovium
- arthroplasty
- reconstruction/fusion
- high risk procedure
- questionable outcomes
what is meant by scleroderma
hardening of the skin
what is meant by myositis
inflammation of the muscles