Rheum 2 - Rheumatoid Arthritis

Question 1

Etiology of RA

Answer 1

specically, unknown, but some genetic basis

Question 2

________ associated with increased incidence of RA and SLE

Answer 2

STAT4 haplotypes (chromosome 2)

Question 3

_____ on chromosome 9 associated with an increased risk of _____ RA

Answer 3

TRAF1-C5

CCP positive RA

**codes an intracellular protein that mediates signal transduction through TNF receptors 1 and 2

Question 4

Primary orchestrator of CMI in immune response of RA

Answer 4

CD4+ T-helper cells

Question 5

White patients with RA express _____ at a much greater rate than non-RA people

Answer 5

HLA DR4

Question 6

Non-white Patients have HLA haplotypes that …

Answer 6

Share epitope (aa sequences) with the HLA DR4

Question 7

DC4 cell stimulates the MQ with ____ + ____ to produce….

Answer 7

IL-2 + IFNg

to produce cytokines - TNFa, IL1/6

Question 8

Cytokines from MQ stimulate production of what?

Answer 8

metalloproteinases, catalepsins, other molecules that cause erosion of bone and cartilage.

–» by Chrondrocytes, Fibroblasts and Osteoclasts

Question 9

IL1 & TNFa stimulate ______

and increase _________

Answer 9

stimulate adhesion molecules

increase recruitment of PMN into joint

Question 10

PMNs release ___ and _____ that degrade cartilage

Answer 10

Elastase and Protease

Question 11

CD4 also stimulate B cells to produce

Answer 11

RF and Ig’s

Question 12

IL4 and IL10 function to…

Answer 12

downregulate inflammatory response

Question 13

Normal synovial membrane is

Answer 13

one cell thick

Question 14

Early RA involves ___ and ___ of synovial lining

Answer 14

hyperplasia and hypertrophy