Introduction to Rheumatology

Question 1

Cartilage is a _____ tissue

Answer 1

avascular

Question 2

____ and _____ is an important part of joint function

Answer 2

Joint capsule and tendon/ligament

Question 3

Collagen fibers are anchored in ____

They entrap ______

Answer 3

subchondral bone

Entrap proteoglycan aggregates

Question 4

Proteoglycan aggregates are very large molecules, they consist of _____ which are very ______

Answer 4

GAGs

very hydrophilic

Question 5

_____ produce all of the components of articular cartilage

Answer 5

Chondrocytes

Question 6

Chondrocytes are supplied by

Answer 6

Synovial fluid produced by synovial membrane

Question 7

What underlies synovial membrane

Answer 7

network of connective tissue (adipose, capillaries, fibrous parynchema)

Question 8

Timeline is important, three examples of disease timeframes

Answer 8

Gout-minute
RA - days to weeks
FM - slow and indolent

Question 9

conditions with few joints

Answer 9

Gout, Seroneg spondyloarthropathies, OA

Question 10

conditions with many joints

Answer 10

RA, SLE, Seroneg spondyloarthropaties, FM

Question 11

Gout responds to _____

Answer 11

NSAIDs

Question 12

FM responds to ____

Answer 12

exercise

Question 13

What helps define therapeutic endpoints?

Answer 13

Functional status

Question 14

Many diseases are characterized by their

Answer 14

extra-articular manifestations

SLE, SN-SA’s

Question 15

Labs are chiefly used to…

Answer 15

support the bedside/observed diagnosis

Question 16

Acute phase proteins

Answer 16

ESR
CRP
Hb
Albumin

Question 17

These drop during inflammation

Answer 17

Hb and albumin

Question 18

___ and ____ help classify polyarticular inflammatory arthritis

Answer 18

RF + ANA

Question 19

Joint fluid should be aspirated when there is…

Answer 19

monoarthritis
undiagnosed polyarthritis
joint swelling out of proportion

Question 20

Fluid analysis can be diagnostic in ___ and _____

Answer 20

crystal-induced arthritis

septic arthritis

Question 21

XRAY can be diagnostic in ___, ___, and _____

Answer 21

A.S.
Calcium pyrophosphate deposition disease
O.A.

Question 22

Muscle strengthening is key in _______

Answer 22

OA and low back pain

Question 23

Mainstay of medicinal therapy

Answer 23

NSAIDs

Question 24

2 functions of NSAIDs

Answer 24

control pain in inflammatory arthritis

abort flare of crystal-induced arthritis

Question 25

These are of benefit in both inflammatory and non-inflammatory arthritis

Answer 25

Corticosteroid injections

Question 26

Corticosteroids can also be useful in…

Answer 26

systemic inflammatory arthritis and other AI conditions

Question 27

What are DMARDs

Answer 27

“Disease-modifying anti-rheumatic drugs”

ex. hydroxychloroquin, gold, MTX