Rheum Flashcards
Risk factors for septic arthritis
Age >80
Diabetes mellitus
Prosthetic joints
Skin infection
Known abnormal joint (Rheumatoid joint)
What to rule out if you suspect acute monoarthritis
Septic until proven otherwise
If possible, hold antibx until fluid sent for culture
Which bacteria is often to blame for septic arthritis
Non-gonococcal (Staph, strep) - most common, most have fever
Gonococcal
-Need to have untreated disseminated gonorrhea
-Usually migratory arthritis
-Possible rash/lesion
Clinical management and Treatment of septic arthritis
Physical exam
Joint aspiration - send for cell count and diff
Blood cultures
GU cultures - gonorrhea
ESR/CRP
Imaging - XR to rule out fracture
Antibx: Broad spectrum while awaiting culture
-Ceftriaxone and Vanc
Causes of acute gout attack
Medical or surgical stress
Dehydration
Excessive ETOH
Changes in medications (particularly diuretics)
Family hx of gout
Males greater risk than females
Clinical presentation of gout attack
Attack typically comes on over hours
Acutely painful, red swollen joint
Possibly fever
Only way to diagnose it is through synovial fluid analysis - +crystals
Presence of tophi is also considered diagnostic
Serum uric acid will often be elevated (except during acute attack)
Treatment of acute gout
NSAIDs (2-3 days)
Colchicine (however can cause diarrhea and joint pain)
Steroids (PO prednisone or intra-articular)
ACTH
Anakinra
DO NOT START ALLOPURINOL
Considerations when starting Allopurinol
Good choice for treating chronic gout
-NEVER START DURING A GOUT ATTACK
Always start in combination with an anti-inflammatory agent
Recheck uric acid every 2-3 weeks and adjust to keep uric acid level less than 6.2
Avoid allopurinol with azathioprine
Avoid allopurinol with amoxicillin
Things to think about when treating someone on Etanercept
Entanercept is a more potent immunosuppressant
If treating someone with acute onset pain in a joint, concern that the joint could be infected. Should stop the immunosuppressant
Presentation of Human Parovirus B19 arthritis
Contact with someone (usually a child - 5ths disease) with a viral illness that then causes bilateral swelling of the wrists, metacarpophalangeal and proximal interphalangeal joints
Treatment is supportive care
Clinical features of rheumatoid arthritis
Polyarthritis (>5 joints)
Symmetrical
Small joint involvement (MCP, PIP, wrists, feet)
Can see ulnar deviation
Inflammatory joint pain (stiff after being sedentary for a bit and then they loosen up)
Worse in the AM but better as the day progresses
6+ weeks of symptoms
More common in women
Diagnostic testing for rheumatoid arthritis
Positive rheumatoid factor (RF)
Cyclic citrullinated peptide (CCP)
—More specific
Elevated ESR/CRP
Low Hgb, HCT (Anemia of chronic disease)
XR of hands and feet
Synovial aspirate would show WBC and inflammation
What are common X-ray findings for rheumatoid arthritis
Soft tissue swelling
Periarticular osteopenia (dark areas on bone)
Joint space narrowing
Marginal erosion
Treatment for rheumatoid arthritis
NSAIDS
Corticosteroids
Classic choice is DMARDs:
Low potency:
-Hydroxychloroquine (Plaquenil) - good for mild disease and safe during pregnancy
Medium potency:
-Methotrexate - once weekly, mouth sores, monitor LFTs
-Leflunomide (Arava)
High potency:
-Biologics and small molecules
—TNF inhibitors - improved when used with DMARDs (methotrexate)
—-Increase risk for infection
Use of Corticosteroids in Rheumatology
Useful first line agents
Often used for life threatening problems or when people are disabled by their problems
In some rare cases, (PMR) can be used as monotherapy however usually utilized as adjunct
Mostly safe during pregnancy (at lower doses)
Hydroxychloroquine: Uses, common side effects
Anti-malarial drug
Used to treat mild to moderate RA and Lupus
Can cause hyperpigmentation
Rare visual field loss
Well documented safe in pregnancy
Methotrexate: Uses and considerations
Cornerstone of treatment in moderate to Severe RA
Also used in lupus, psoriatic arthritis, myositis, vasculitis
Given once weekly PO or SC
Onset is 4-8 weeks
Can cause painful oral mucosal ulcers
- Folic acid given for side effects
Can cause LFT elevation