Rhabdovirus

Question 1

Structure

Answer 1

Envelope
Peplomers spikes
Single stranded negative sense RNA
RNA dependent RNA polymerase

Question 2

Peplomers spikes composed of

Answer 2

Viral glycoprotein

Question 3

Inside the envelope

Answer 3

Ribonuceocaspid

Question 4

Belong to the genus

Answer 4

Lyssavirus

Question 5

Survives storage at

Answer 5

4 degree C weeks

-70 degree C years

Question 6

Killed rapidly by

Answer 6

UV light
Heat
Lipid solvent
Trypsin detergents

Question 7

Virus attaches to cells via

Answer 7

Glycoprotein spikes

Question 8

Receptor

Answer 8

Nicotinic acethylcholine receptor

Question 9

How many RNA species

Answer 9

5

Question 10

Template for transcription is the genome RNA in the form of

Answer 10

Ribonucleoprotein RNP

Question 11

Monocistronic mRNAs for five virions proteins

Answer 11

Nucleocapsid
Polymerase proteins
Matrix
Glycoproteins

Question 12

Required replication

Answer 12

Viral N and P

Question 13

Particles acquire an envelope by budding through the

Answer 13

Plasma membrane

Question 14

Inner side of the envelope

Answer 14

Viral matrix

Question 15

Outer side of the envelope that form spikes

Answer 15

Viral glycoprotein

Question 16

Intermediate susceptibility include

Answer 16

Skunks
Raccoons
Bats

Question 17

Recovery from infection is rare except

Answer 17

Certain bats

Question 18

May transmit virus for months without showing any signs of disease

Answer 18

Vampire bats

Question 19

Street virus long incubation period

Answer 19

21-60 days in dogs

Question 20

Fixed or mutant virus multiplies rapidly, and the incubation period is shortened

Answer 20

4-6 days

Question 21

Serotype

Answer 21

Single

Question 22

Major factor in rabies virus neuroinvasiveness and pathology icily

Answer 22

G- glycoprotein

Question 23

Substitution at amino acid _________ of the glycoprotein results in loss of virulence

Answer 23

Positon 333

Question 24

Used in diagnostic immuno fluorescence for rabies

Answer 24

Antiserum prepared against the purified nucleocapsid

Question 25

Virus multiplies at the

Answer 25

Site of inoculation

Question 26

Possible enter the nervous system directly without

Answer 26

Local replication

Question 27

Multiplies in the central nervous system then develop

Answer 27

Encephalitis

Question 28

Organ with the highest titers of virus is the

Answer 28

Submaxillary salivary

Question 29

Shorter incubation period bite in

Answer 29

Face

Question 30

Pathognomonic sign

Answer 30

Negri bodies

Question 31

2-10 days, may show any of the following nonspecific symptoms

Answer 31

Short Prodromal phase

Question 32

2-7 days, patients show signs of nervous system dysfunction, hydrophobia or aerophobia

Answer 32

Acute neurologic phase

Question 33

Last phase lead to death

Answer 33

Coma

Question 34

Major cause of death

Answer 34

Cardiorespiratory arrest

Question 35

Paralytic rabies

Answer 35

Bat rabies virus

Question 36

Incubation period in dogs

Answer 36

3-8 weeks but it may be as short as 10 days

Question 37

Grown in the MRC -5 human diploid cell line

Answer 37

Human diploid cell vaccine

Question 38

Ultrafiltration and activated with b propiolactone

Answer 38

Human diploid cell vaccine

Question 39

No serious anaphylactic or encephalitic reactions have been reported

Answer 39

Human diploid cell vaccine

Question 40

Flury LEP Chicken fibroblast B- propiolactone Zonal centrifugation

Answer 40

Purified chick embryo cell vaccine

Question 41

Fetal Rhesus monkey lung cells Beta propiolactone Aluminum phosphate

Answer 41

Rabies vaccine, adsorbed

Question 42

Made from infected sheep, goat or mouse brains | It causes sensitization to nerve tissue and results in postvaccinal encephalitis

Answer 42

Nerve tissue vaccine

Question 43

Developed to minimize the problem of postvaccinal encephalitis

Answer 43

Duck embryo vaccine

Question 44

Used for animals but not for human

Answer 44

Live attenuated viruses

Question 45

Types of rabies antibody Gamma globulin prepared by cold ethanol fractionation from the plasma of hyper immunized humans

Answer 45

Rabies immune globulin, human (HRI G)

Question 46

Types of rabies antibody Concentrated serum from horses hyper immunized with rabies virus It has been used in countries where HRIG is not available

Answer 46

Anti rabies serum, equine

Question 47

The goal is to attain an antibody level presumed to be protective by means of vaccine administration prior to any exposure

Answer 47

Pre exposure prophylaxis

Question 48

Most common cause of death

Answer 48

10th

Question 49

Children age

Answer 49

5-15

Question 50

Human to human involved transmitted by corneal and organ transplants

Answer 50

Liver and kidney

Question 51

Proved effective at controlling rabies in foxes in Europe

Answer 51

V-RG

Question 52

Synthesized by membrane- bound ribosome attach to host cell and internalized by Endocytosis. Generates neutralizing antibodies

Answer 52

G

Question 53

Major structure protein, protects the RNA from ribonuclease digestion

Answer 53

N

Question 54

Constitute the RNA dependent RNA pol which transcribe the viral genomic RNA

Answer 54

L and NS

Question 55

Matrix protein | Lies between envelope and nucleocapsid

Answer 55

M

Question 56

Primary test to determine the presence of rabies

Answer 56

FAT

Question 57

Highly sensitive test for rabies which takes 2-3 weeks to complete

Answer 57

Mouse inoculation test

Question 58

Used to confirm the diagnosis

Answer 58

Sellers stain

Question 59

Perfectly tolerated and safe but the cost is expensive Must be infiltrated around the bite site Immune

Answer 59

HRIG

Question 60

From horses so skin test is required | Effective and safe with an adverse reaction rate of

Answer 60

ERIG

Question 61

Ideal for human

Answer 61

Human diploid cell vaccine

Question 62

Cheaper

Answer 62

Purified Veronica Cell Rabies Vaccine

Question 63

Shaped

Answer 63

Rod or bullet shaped