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Microbiology 2nd Sem Finals > Flavivirus > Flashcards

Flavivirus Flashcards

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1
Q

Flavivirus are

A 
Yellow fever virus
Dengue virus
St. Louis encephalitis virus
Japanese encephalitis virus
West Nile virus
Murray valley 
Tick bone
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2
Q

Yellow fever

Vector

A

Aedes aegypti

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3
Q

Yellow fever

Location

A

Latin America, Caribbean, Africa

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4
Q

Yellow fever

Manifestation

A

Jaundice
Hemorrhage
Albumin urea

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5
Q

Yellow fever

Microscopy

A

Hepatic necrosis
Councilman
Torres bodies

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6
Q

Yellow fever

Diagnosis

A

Cell culture
Serology
PCR
Immunohistochemistry

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7
Q

Yellow fever

Vaccine

A

Live attenuated 17D vaccine

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8
Q

Dengue fever

Has 4 types

A

DEN 1-4

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9
Q

Dengue fever

Vector

A

Aedes aegypti

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10
Q

Dengue fever

Most common presentation

A

Undifferentiated fever

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11
Q

Dengue fever

Inflate blood pressure cuff to a point midway between systolic and diastolic pressure for 5 minutes

A

Tourniquet test

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12
Q

Dengue fever

Tourniquet test positive result

A

20 or more petechiae per 1 inch

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13
Q

Dengue fever

4 necessary criteria

A

Fever
Hemorrhagic manifestations
Low platelet count
Leaky capillaries

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14
Q

Dengue fever

Leak capillaries

A

Elevated hematocrit
Low albumin
Pleural or other effusions

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15
Q

Dengue fever

Evidence of circulatory failure manifested indirectly by all of the ff

A

Rapid and weak pulse
Narrow pulse pressure
Cold, clammy skin
Altered mental status

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16
Q

Dengue fever

Direct evidence of circulatory failure

A

Frank shock

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17
Q

Dengue fever

Alarm signals

A

Severe abdominal pain
Prolonged vomiting
Abrupt change from fever to hypothermia
Change in level of consciousness

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18
Q

Dengue fever

Four criteria

A

Fever
Hemorrhagic manifestations
Excessive capillary permeability

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19
Q

Dengue fever

Initial warning

A

Disappearance of fever
Drop in platelets
Increase in Hct

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20
Q

Dengue fever

When PT develops DSS

A

3-6 days after onset of symptoms

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21
Q

Dengue fever

Clinical laboratory test

A

CBC, WBC, platelet, hematocrit
Albumin
Live function test
Urine

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22
Q

Dengue fever

Specific test

A

Virus isolation

Serology

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23
Q

Dengue fever

To determine serotype of the infecting virus

A

Virus isolation

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24
Q

Dengue fever

Test for serologic diagnosis

A

IgM ELISA

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25
Q

Dengue fever

No hemorrhagic manifestations and patient is well hydrated

A

Home treatment

26
Q

Dengue fever

Hemorrhagic manifestations or hydration borderline

A

Consider hospitalization

27
Q

Dengue fever

Warning sign even without shock

A

Hospitalize

28
Q

Dengue fever

Management

A 
Fluids
Antypiretics (avoid aspirin and NSAIDS )
Monitor BP, hematocrit, platelet
Blood product when needed
Level of consciousness
29
Q

Dengue fever

Mosquito barriers

A

Only needed until fever subsides, to prevent Aedes aegypti mosquitoes from biting patients and acquiring virus
Keep patient in screened sickroom or under a mosquito net

30
Q

Dengue fever

Prevention

A

Public education
Vector control
Vaccine in developmant

31
Q

Single serotype, 5 genotype-based on E protein

Asia, including SEA

A

Japanese encephalitis virus

32
Q

Japanese encephalitis virus

Cycle

A 
Birds
Culex mosquitoes
Swine
Humans
Horses
33
Q

Japanese encephalitis virus

Manifestations

A

Lethargy
Behavioral changes
Motor abnormalities

34
Q

Japanese encephalitis virus

Diagnosis

A

CSF analysis
EEG
IgM ELISA
NT

35
Q

Japanese encephalitis virus

Treatment

A

Supportive

36
Q

Japanese encephalitis virus

Prevention

A

Inactivated vaccine (3yr protection)

37
Q

Famous flavi virus

A

Vector borne transmitted by mosquitoes

38
Q

Yellow fever

Pathology involvement

A

Hepatic cirrhosis

Renal involvement

39
Q

Yellow fever

Dx

A

Reverse transcriptase

40
Q

Yellow fever

Vaccine

A

Given 2 weeks before departure to Africa

41
Q

Dengue fever

Most common serotype

A

Type 2

42
Q

Dengue

1st infection

A

Mild dengue fever

43
Q

Dengue fever

2nd infection

A

More serious, DHF, plasma loss and plasma leakage

44
Q

Aedes aegypti

A

Male bites plants
Flies house to house
Can’t fly long distance

45
Q

Dengue most common site of bleeding

A

GIT

46
Q

Tourniquet test

A

+ not always dengue

- not always absence of dengue

47
Q

Dengue manifestation of leaky capillary or plasma loss

A

2-7 days usually 4-5 days

Fever gone - platelet fall

48
Q

Dengue

Narrow PP

A

Push fluid fast drip PNSS/PLR

49
Q

Dengue

Weak PP that sign of shock

A
50
Q

Dengue
Lab test

WBC

A

High then low

51
Q

Dengue

Virus isolation

A

Cell lines T lymphocytes

Monkey kidney cell

52
Q

St. Louis encephalitis, Murray valley encephalitis, West Nile fever

Structure

A

40-60 nm in diameter
Positive sense
Single stranded RNA
Envelope

53
Q

St. Louis encephalitis, Murray valley encephalitis, West Nile fever

Other description

A

3 structural polypeptides

Two glycosylated

54
Q

St. Louis encephalitis, Murray valley encephalitis, West Nile fever

Replication

A

Cytoplasm

55
Q

St. Louis encephalitis, Murray valley encephalitis, West Nile fever

Assembly

A

Within endoplasmic reticulum

56
Q

Japanese encephalitis fever

Location

A

Central luzon and bicol region

57
Q

Japanese encephalitis fever

Animal reservoir

A

Swine and horses

58
Q

Japanese encephalitis fever

Mostly seen in

A

Rice fields

59
Q

Japanese encephalitis fever

Dx

A

ELISA blood ans CSF

60
Q

Structure

A 
Small
Spherical
Enveloped
SS RNA
Cross related

Microbiology 2nd Sem Finals (2 decks)

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