Rhabdomyolysis Flashcards
1
Q
What is the pathophysiology of Rhabdomyolysis?
A
Skeletal muscle breakdown causing release of K+, PO4, urate, Myoglobin, CK
Hyperkalaemia
AKI
2
Q
What can cause Rhabdomyolysis?
A
Ischaemia - Embolism, Surgery
Trauma - Immobilisation, Crush, Burns, Seizures, Compartment syndrome
Toxins - Statins, Ecstasy, Fibrates
3
Q
What is the clinical presentation of Rhabdomyolysis?
A
Muscle pain
Swelling
Red/Brown urine
AKI follows 12 hours later
4
Q
What investigations can be done in a patient with suspected Rhabdomyolysis?
A
Dipstick: +ve Hb, -ve RBCs
Blood: ↑CK, ↑K, ↑PO4, ↑urate
5
Q
What is the management of Rhabdomyolysis?
A
Manage hyperkalaemia Fluids Monitor CVP is oligouric IV NaHCO3 may be used to alkalinize urine and stabilise a less toxic form of myoglobin.
