Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

BB > RH > Flashcards

RH Flashcards

1
Q

The Rh system genes are:
a. RHD and RHCE.
b. RHD and LW.
c. RHD and RHAG.
d. RHCE and RHAG.

A

A

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

RHD and RHCE are proposed by __________; Located on chromosome ____

A

Tippett; 1

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

RHAG gene is located on chromosome ____

A

6

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

RHAG gene can express any Rh antigen. RHD controls the expression of RhD.

A. S1 is true
B. S2 is true
C. Both are true
D. Both are False

A

B

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Presence of 3 separate genes D,C,E and alleles c and e

A

Fisher-Race (DCE Nomenclature)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Most common in blacks (Weiner)

A

R0r

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Most common in Asians/Whites

A

R1r

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

African-Americans

A

R0>r>R1>R2

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Caucasians

A

R1>r>R2>R0

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

A system that assigns a number to each antigen in order if its discovery or recognized relationship to the Rh system

A

Rosenfield (Alpha-numeric Terminology)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

ISBT

A

International Society of Blood Transfusion

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

In ISBT Nomenclature, the first 3 numbers represent the system, While the Last 3 numbers represent the ANTIGENIC SPECIFICITY.

A

A. Only one statement is true
B. Both statements are true
C. None of the statements are correct.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Correct order of Immunogenecity:

A

D>c>E>C>e

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Common in Blacks, No or weak with anti-D

A

Weak D

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Weak D is detected by _________

A

Indirect Antihuman Globulin Test

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Allele carrying RHD is in trans position with the allele carrying C

A

C in Trans to RHD

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Anti D is fewer in number but still completely expressed

A

Genetic Weak D

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Missing or altered D protein epitope

A

Partial D

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Rh of a Partial D donor

A

Rh Positive

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Rh of a Partial D recipient

A

Rh negative

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Increased number of D antigens on RBC

A

Rh Deletion

22
Q

Antigen is not expressed on RBC due to an abnormality in Transmebrane Protein

A

Rh null

23
Q

Type of Rh null that has mutation in RHCE, Deletion of RHD and Normal RHAG gene

A

Amorphic type of RH Null

24
Q

Type of RH null that has mutation in RHAG gene

A

Regulator Type

25
Q

Partial suppression of RH gene; weakened Rh antigen
expression

A

Rh mod

26
Q

A compound antigen; expressed when ‘c’ and ‘e’ are in cis
position = f antigen

A

f (ce)

27
Q

Caused by single amino acid change on RhCe protein

A

Cw

28
Q

A compound antigen; expressed when ‘C’ and ‘e’ are
present

A

rhi (Ce)

29
Q

Present on most D+ and C+ RBCs

A

G (DC)

30
Q

Strong D expression because of no Cc/Ee

A

Exalted D

31
Q

Most clinically significant IgG

A

IgG1 and 3

32
Q

IgG for complement fixation

A

IgG3>IgG1>IgG2

33
Q

Best at crossing placenta

A

IgG1>IgG4>IgG3

34
Q

Greatest significance because RBCs coated with these are c leared in the RES

A

IgG1/IgG2

35
Q

Antigen present on Rhesus monkey and on majority of human RBCs

A

Landsteiner-Weiner blood group system

36
Q

LW gene is on chromosome ____; Antigen is carried by ________

A

19, ICAM-4

37
Q

Differentiate D antigen to LW antigen

A

DTT or Dithiothreitol

38
Q

Specimen used for routine RH typing

A

Whole blood or RBC suspension

39
Q

What Rh antigen is found in 85% of the Caucasian pop-
ulation and is always significant for transfusion purposes?

a. d
b. c
c. D
d. E

A

C

40
Q

How are weaker-than-expected reactions with anti-D
typing reagents categorized?
a. Rhmod
b. Weak D
c. DAT positive
d. Dw

A

b

41
Q

Cells carrying a weak D antigen require the use of what
test to demonstrate its presence?
a. Indirect antiglobulin test
b. Direct antiglobulin test
c. Microplate test
d. Warm autoadsorption test

A

A

42
Q

How are Rh antigens inherited?
a. Autosomal recessive alleles
b. Sex-linked genes
c. Codominant alleles
d. X-linked

A

C

43
Q

Biochemically speaking, what type of molecules are Rh
antigens?
a. Glycophorins
b. Simple sugars
c. Proteins
d. Lipids

A

C

44
Q

Rh antibodies react best at what temperature (°C)?
a. 15
b. 18
c. 22
d. 37

A

D

45
Q

Rh antibodies are primarily of which immunoglobulin
class?
a. IgA
b. IgD
c. IgG
d. IgM

A

C

46
Q

Rh antibodies have been associated with which clinical
condition?
a. Hemolytic disease of the fetus and newborn
b. Thrombocytopenia
c. HemophiliCa A
d. Stomatocytosis

A

A

47
Q

What do Rhnull cells lack?
a. Lewis antigens
b. Normal oxygen-carrying capacity
c. Rh antigens
d. Hemoglobin

A

C

48
Q

Convert the following genotypes from Wiener nomen-
clature to Fisher-Race and Rosenfield nomenclatures,

and list the antigens present in each haplotype.
a. R1r
b. R2R0
c. RzR1
d. r’r

A
49
Q

Which Rh phenotype has the strongest expression of D?
a. DCe/ce
b. DCe/DCe
c. DcE/DcE
d. D–

A

D

50
Q

An individual has the following serologic reactions:
D+C+E+c+e+f–. What is the most probable genotype?
a. R1R2
b. R0ry
c. Rzr
d. R1r”

A

A

51
Q

Which of the following is the most common haplotype
in the African American population?
a. DCe
b. DcE
c. Dce
d. ce

A

C

52
Q

If a patient who is R1R1 is transfused with RBCs that are
Ror, which antibody is he most likely to produce?
a. Anti-D
b. Anti-c
c. Anti-e
d. Anti-G

A

B

BB (3 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions