Review Genomics Flashcards
Contig
An arrangement of overlapping cloned DNA sequences without gaps
Scaffold
The result of connecting contigs by linking info from paired end reads
Molecular enhancers
DNA sequences near the exons of a gene that bind transcription factors and affect transcription
Genomic library
A collection of DNA fragments representing the genome of an organism
Paired end reads
Sequences that come from either end of a cloned DNA fragment of a certain size.
ESTs
Sequence reads of fixed length from Both ends of a cDNA clone
Synteny
The conserved order of orthologous genes/loci on a chromosome.
Complementation test
Method of discovering whether two mutations are in separate genes
Haplotype
Combination of alleles at multiple loci on the same chromosomal homolog
Ortholog
A gene whose sequence is highly conserved in several different species
cDNA library
A collection of DNA fragments representing the transcriptome of an organism
Founder effect
Random difference in allele frequencies in a new population that breaks off from a preexisting population
Reporter gene
A gene whose expression is easily monitored
