Review

Question 1

What is Niemann Pick Dz?

Answer 1

Inability to break down ASMase

Spingomyelin will accumulate in the liver, spleen, bone marrow and CNS.

Hall mark: cherry red spot in eye

Question 2

[Q:] Examples of carbs on the membrane?

Answer 2

• Glycocalyx and antigens

Question 3

[Q:] What is spur cell anemia?

Answer 3

• Spur cell anemia occurs when there is too much cholesterol in the membrane of our RBC. The membranes become too rigid when they pass through the [capillaries of the spleen], they break.

Question 4

[Q:] What is P-type ATPase?

Answer 4

The ATPase is directly phosphorylated at a ASPARTATE residue and a covent bond is formed

Question 5

Na/Glucose pump is a ______

Answer 5

symport.

Moves both inside in the cell

Question 6

[Q:] How can we maintain low levels of Calcium inside the cell?

Answer 6

NACX (NaCa Aniporter)

3 Na+ are moved in
1 Ca+ is moved out

Question 7

Dz of Transporters

Answer 7

1. CF
2. Cytinuria–> defect in transporters that uptake cystine, argining, lysine and ornithine)
3. Hartnup

Question 8

Hartnups Dz

Answer 8

3. Hartnups disease–> a defect in the transporters of non-polar, neutral AA (such as trytophan, alanine, leucine, valine and threonone)

Question 9

Cardiotonic drugs

Answer 9

Inhibit Na/K+

build up of Na+ inside the cell

turn off NaCX (which want to move Na+ in and Ca2+ out)

So we also have a Ca2+