Review

Question 1

1. ) CLL: Arch? Cells? CD19/20? CD10/BCL6? Special marker/ translocation?
2. ) FL: Arch? Cells? CD19/20? CD10/BCL6? Special marker/ translocation?
3. ) MCL: Arch? Cells? CD19/20? CD10/BCL6? Special marker/ translocation?
4. ) BL: Arch? Cells? CD19/20? CD10/BCL6? Special marker/ translocation?

Answer 1

1. ) Diffuse; small with dark chrom; +; -; none
2. ) Nodular; small and irreg; +; +; BCL2 (suppress apoptosis; t:14:18
3. ) Diffuse; small; +; -; CyclinD1/BCL1 cell cycle; t11:14
4. ) Diffuse; Medium, starry night; +; +; MYC t8:14

Question 2

• Unique CHL markers?
• PCN: MGUS?
• Plasmacytoma?
• PCM?
• How to type ab test?
• Myelofibrosis can lead to? Cells?

Answer 2

• CD 15/CD30; no CD19/20
• Just increased protein
• Only bone
• Crab
• Leukoerythrostasis