Granulocyte/Monocyte Disorders Flashcards
1
Q
- Neotrophils: Turnover? Pool storage?
- Eosinophils: Produced under influence of? Lobes? Survive how long?
- Basophils: Lobes? Similar size to? Receptors for? Role?
- Monocyte: Days in marrow? Storage? In IV compartments how long? Roles? (3)
- Neutropenia: Decreased what? (2) Varies with? (3) 500/ml?
A
- 1-2 days; 10-14 days
- IL5; 2; weeks; allergies, parasites, response to tumors
- 2; eisoino; IgE; Hypersensitivity allergic reactions
- 7 days (short); None; 3-5 days; move to site of infection; filter; present antigens
- Bands and segs; age, race, altitude; normal to mild risk; moderate risk of infection; severe risk
- Increase WBC; infecion, inflamm., stress, malignancy
- Increase in WBC precursors in blood; immature:mature white cells
- > 350/ul; allergies, parasite, drug
- drug/food hypersens, hives, CML
- > 95/ml’ chronic infection
- laminar; C3B; Yes, reactive O2 species; Yes, Proteases; ingestion and degranulation/killing
2
Q
- Neutropenia: Decreased Marrow Production:
1. ) Primary:
a. ) Kosimann syndrome: Severe neutropenia where? Myeloid production? Genetics? (3) Many infections when?
b. ) Schawachmann Diamond: Signs? (3) Inheritance? May lead to? (3)
c. ) Cyclin enutropenia: Neutropenia cycles? Genetics? (3) Gene mutation?
2. ) Secondary:
a. ) Drug induced: Ex? (2)
b. ) Viral infection: Ex? (2)
c. ) Nutritional deficiency ex? (3)
3. ) Other: Chediak Hegashi?
A
a. ) peripheral blood; down; AR/AD/spradic; first few months
b. ) Neutropenia, pancreatic insuff., fat metabolism problems; AR; MDS,leukemia, aplastic anemia
c. ) Severe penia for 5-7 days with 15 day cycle; AR/AD/sporadic; elastase
a. ) chemo or penicllin killing stem cells
b. ) HIV, measles, hep supress BM production
c. ) Folate, b12, copper, protein
3. ) Specific granule deficiency
3
Q
- Neutropenia: Increased turnover:
1. ) Immune:
a. ) Chronic benign neutropenia of childhood: Ab cross react with? for how long?
b. ) Autoimmune: Ab against? (2)
c. ) Alloimmune: Type of transfer? Ex?
2. ) Non-immune:
a. ) Infection?
b. ) Splenomegaly: Cause?
c. ) Pseudoneutropenia: Infection with excess what? - Neutropenia treatments? (3)
A
a. ) Neutrophils; 6-54 months
b. ) neutrophils and other myeloid maybe
c. ) Passive; moms abs against babies
a. ) Yes
b. ) Excessive sequestration in spleen
c. ) C5a
- Antibiotics, G-CSF to help production, IVIG
4
Q
- Dysfunction Diseases:
1. ) Leukocyte Adhesion Deficiency 1: Due to? Inheritance? Recurrent infections where? Delayed?
2. ) LAD2: Abnormal? Recurrent? RBC’s? Genetics?
3. ) Actin Dysfunction: Type of disorder? Wound healing? Infections?
4. ) Specific Granule deficiency: Type of defect? Recurrent infections where? Chemotaxis? Microcidal activity? Genetics? Low prod of?
5. ) Myeloperoxidase deficiency: Type of defect? Increase type of infections? Genetics? Type of mutation?
6. ) Chediak Hegoshi Syndrome: Type of defect?
7. ) Chronic granulomatous disease: Type of disease? Type of infections? Leads to? (2)
A
- ) CD18 deficiency; AR; Soft tissue; umbilical sep.
- ) Transferase; infections/short stature; also affected; AR bombay phenotype
- ) Chemotactic; poor; many
- ) granule; deep tissue; poor; poor; AR; granule
- ) Granule; fungal; AR; post trans mod
- ) Granule
- ) Oxygen radical disease; cat (+) infections; neutrophilia and granulomas
5
Q
- NADPH oxidase system: Superoxidase made by trnasferring what? Coupled with? Leads to? (2) Helps breakdown what? (2) Diagnostic test? Can lead to?
- Defects in phago function lead to? (3)
- Defects in compliment leads to? (2) Similar to?
- Management for dysfunction disorders? (5)
A
- e- to NADPH; O2; hydrogen peroxide H2O2 and oxygen radicals; bacteria and fungi; Nitro blue (reduces blue dye if good); chronic gran. disease
- Increased infections, incr. cat (+) infections, increased periodontal disease
- Influenza and pneomonia; Ab deficiency
- Antibiotics, G-SCF; cytokine therapy, stem cell treatment; gene therapy
