REVERSIBLE CHANGES/ NECROSIS/ APOPTOSIS Flashcards

1
Q

WHAT ARE THE GROSS CHANGES IN REVERSIBLE

A
  1. Organ Pallor
  2. Increased Weight
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2
Q

Microscopic Changes in reversible changes

A

1Fatty degeneration
2. Cellular swelling

“FC”

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3
Q

In IRREVERSIBLE CHANGEs what are the cytoplasmic changes that appear

A
  1. cloudy swelling
  2. increased eosinophilia
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4
Q

W hat are the Nuclear Changes noticeable in irreversible changes?

A

1.Pyknosis
2.Karyolysis
3.Karyorrhexis

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5
Q

condensation of nucleus

A. Pyknosis
B.Karyolysis
C.Karyorrhexis-

A

A. Pyknosis

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6
Q

Fragmentation or segmentation of nucleus
A. Pyknosis
B.Karyolysis
C.Karyorrhexis-

A

B.Karyolysis

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7
Q

dissolution of nucleus

A. Pyknosis
B.Karyolysis
C.Karyorrhexis
d. APOPTOSIS

A

C.Karyorrhexis

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8
Q

the 2 patterns of cell death

A

apoptosis and necrosis

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9
Q

Normal cell death except for stable and permanent cell

A

APOPTOSIS

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10
Q
  • Death of single cell in a cluster of cells
  • Has CELL SHRINKAGE

a. apoptosis
b. necrosis

A

apoptosis

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11
Q

TRUE OR FALSE
APOPTOSIS HAS CELL SHRINKAGE

A

TRUE

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12
Q

WHAT ARE THE 5 Chief Morphological
Features OF APOPTOSIS

A
  1. Chromatin condensation
  2. Chromatin fragmentation
  3. Cell shrinkage
  4. Cytoplasmic bleb formation
  5. Phagocytosis of apoptotic cells
    “CCCCP”
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13
Q

Death of cell due to a disease

A. APOPTOSIS
B. NECROSIS

A

B. NECROSIS

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14
Q

TRUE OR FALSE
IN NECROSIS THE CELL SWELL

A

TRUE

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15
Q

Due to sudden cut off of blood and oxygen supply; enzymes are BLOCKED

A. Liquefactive Necrosis
B. Coagulative Necrosis
C. Caseous Necrosis
D. Fibrinoid Necrosis

A

B. Coagulative Necrosis

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16
Q

Cell death is due to ISCHEMIA

A. Liquefactive Necrosis
B. Coagulative Necrosis
C. Caseous Necrosis
D. Fibrinoid Necrosis

A

B. Coagulative Necrosis

17
Q

Microscopically: Cell outlines are preserved/maintained; appears GHOSTLY

A. Liquefactive Necrosis
B. Coagulative Necrosis
C. Caseous Necrosis
D. Fibrinoid Necrosis

A

B. Coagulative Necrosis

18
Q
  • On gross: Affected organs are somewhat firm, appearing like a boiled material (solid organs: kidney, liver, heart)
  • i.e. Myocardial infarction

A. Liquefactive Necrosis
B. Coagulative Necrosis
C. Caseous Necrosis
D. Fibrinoid Necrosis

A

B. Coagulative Necrosis

19
Q

Appears liquidy, creamy yellow (due to increase pus)

A. Liquefactive Necrosis
B. Coagulative Necrosis
C. Caseous Necrosis
D. Fibrinoid Necrosis

A

A. Liquefactive Necrosis

20
Q
  • Softening of organs is due to the action of hydrolytic enzyme
  • There is complete digestion of cells
A

Liquefactive
Necrosis

21
Q

EXAMPLES ARE: brain infarction, suppurative bacterial infection

A. Liquefactive Necrosis
B. Coagulative Necrosis
C. Caseous Necrosis
D. Fibrinoid Necrosis

A

A. Liquefactive Necrosis

22
Q

Cheese like-appearance

A. Liquefactive Necrosis
B. Coagulative Necrosis
C. Caseous Necrosis
D. Fibrinoid Necrosis

A

C. Caseous Necrosis

23
Q

Combination of liquefactive and coagulative necrosis

A. Liquefactive Necrosis
B. Coagulative Necrosis
C. Caseous Necrosis
D. Fibrinoid Necrosis

A

C. Caseous Necrosis

24
Q

Microscopically: Appears as amorphous granular debri surrounded by granulomatous inflammation

A. Liquefactive Necrosis
B. Coagulative Necrosis
C. Caseous Necrosis
D. Fibrinoid Necrosis

A

C. Caseous Necrosis

25
Q

On gross: Affected organs appear greasy, resembling cheese

A

C. Caseous Necrosis

26
Q

Usually seen in Tuberculosis (TB)

A. Liquefactive Necrosis
B. Coagulative Necrosis
C. Caseous Necrosis
D. Fibrinoid Necrosis

A

C. Caseous Necrosis

27
Q

Seen in immune reactions of the vessel

A. Liquefactive Necrosis
B. Coagulative Necrosis
C. Caseous Necrosis
D. Fibrinoid Necrosis

A

D. Fibrinoid Necrosis

28
Q

Deposition of fibrin in the vessel wall which appears thick under the microscope

A. Liquefactive Necrosis
B. Coagulative Necrosis
C. Caseous Necrosis
D. Fibrinoid Necrosis

A

D. Fibrinoid Necrosis

29
Q

*Gross appearance cannot be noted (changes are too small to be observed on gross)

*MICROSCOPICALLY ONLY!!

A. Liquefactive Necrosis
B. Coagulative Necrosis
C. Caseous Necrosis
D. Fibrinoid Necrosis

A

D. Fibrinoid Necrosis

30
Q
  • Adipose Cells
  • Destruction of fat cells due to release of pancreatic lipases
  • Death of fat tissues due to loss of blood supply

A. Liquefactive Necrosis
B. Fat necrosis
C. Caseous Necrosis
D. Fibrinoid Necrosis

A

B. Fat necrosis

31
Q

On gross: necrotic material appears chalky-white precipitate

A. Liquefactive Necrosis
B. Fat necrosis
C. Caseous Necrosis
D. Fibrinoid Necrosis

A

B. Fat necrosis

32
Q
  • On microscopy: infiltrates of foamy macrophage adjacent to adipose tissues
  • Seen in pancreatitis

A. Liquefactive Necrosis
B. Fat necrosis
C. Caseous Necrosis
D. Fibrinoid Necrosis

A

B. Fat necrosis

33
Q
  • Affected organ is usually the breast

A. Liquefactive Necrosis
B. Fat necrosis
C. Caseous Necrosis
D. Fibrinoid Necrosis

A

B. Fat necrosis

34
Q

Secondary to Ischemia

A. Liquefactive Necrosis
B. Fat necrosis
C. Gangrenous necrosis

A

C. Gangrenous necrosis

35
Q
  • NOT a specific pattern of necrosis
  • Refers to a limb that has lost its blood supply

A. Liquefactive Necrosis
B. Fat necrosis
C. Gangrenous necrosis

A

C. Gangrenous necrosis

36
Q
  • Affected skin looks dry, appears black, and observed in various stages of
    decomposition

A. Liquefactive Necrosis
B. Fat necrosis
C. Gangrenous necrosis

A

C. Gangrenous necrosis

37
Q

-Due to venous occlusion (occluded vessel)

  • EMBOLISIM OF FOOD

A. WET GANGRENE
B Dry gangrene

A

WET GANGRENE

38
Q

-Due to arterial occlusion (occluded artery)

-i.e. Bacterial infection

A. WET GANGRENE
B Dry gangrene
C. Gangrenous
Necrosis

A

B Dry gangrene

39
Q
A