Reversal Agents

Question 1

Dose for Flumazenil as reversal?

Answer 1

• 0.2 mg slow titration up to 1mg
  (3 mg for OD)

Nagelhout 7th edition, Ch. 9, pg. 115

Question 2

Onset/DoA Flumazenil

Answer 2

• Onset: 1-2 min
• Duration: 45-90 min

Nagelhout 7th edition, Ch. 9, pg. 115

Question 3

NALOXONE
Opiate overdose dosing

Answer 3

Opiate overdose:

• 0.2-4 mg IV q2-3 min PRN (max 10 mg)
• Infusion: 0.4 mg/hr and titrate to effect

CAREFUL TITRATION

Question 4

NALOXONE
Opiate-induced respiratory depression dosing

Answer 4

Reversal of opiate-induced respiratory depression:

• 0.04-0.4 mg IV q2-3 min
• Load: 5 mcg/kg
• Infusion: 2.5-160 mcg/kg/hr

CAREFUL TITRATION

Question 5

NALOXONE
Opiate-induced pruritis dosing

Answer 5

• 0.25 mcg/kg/hr