retroviruses

Question 1

gag

Answer 1

matrix (MA), capsid (CA), and nucleic acid–binding (NC) proteins

Question 2

POL

Answer 2

h a protease (PR) responsible for cleaving the viral polyproteins
and a
reverse transcriptase (RT). In addition, HIV
pol
encodes an integrase (IN

Question 3

what are the AIDS definign cancers

Answer 3

Kaposi sarcoma (HHV-8)
NHL (EBV)
Invasive Cervical Cancer (HPV)

there has been a reduction in these cancers with HAART)

Question 4

non- aids definign cancers

Answer 4

Non-­AIDS-­defining cancers

Hodgkin's disease;;
multiplemyeloma;; 
leukemia;; 
melanoma;; 
cervical, brain, testicular, oral, lung, gastric, liver, renal,
and anal cancers

these cancers are increasing even with tx

Question 5

HTLV

Answer 5

delta retrovirus that infects T cells–
japan, carribean, africa, s. america

route- syringes, mother to child, Sex, blood exposure

Question 6

diseases associated with HTLV

Answer 6

adult T cell leukemia/lymphoma ATL
tropical spastic paresis
uveitis

Question 7

ATL

Answer 7

ATL (adult T-­cell leukemia) is a lymphoproliferative disorder clinically -enlargement peripheral lymph nodes, skin lesions due to leukemic cell infiltration, lytic bone lesions and hypercalcemia.

Question 8

tropical spastic paresis

Answer 8

MS like weakness, stiffness of lower extremities

Question 9

Tx of ATL

Answer 9

chemo, antiretroviral +inf alpha

bone marrow transplant