respirataory viruses Flashcards
URT infections only
rhino
corona
URT and LRT infections
influenza
parinfluenza
RSV
adeno
Acute Infection with
primary replication confined to
respiratory mucosal surface
Paramyxovirus
Orthomyxovirus ,
Coronavirus,
Picornavirus(rhinovirus)
Persistent replication on
respiratory mucosal surface
adenovirus
Systemic replication after
primary replication on
respiratory mucosal surface
Paramyxovirus (mumps, measles),
Rubella,
orthomyxvirus
influenza
enveloped
- segmented single stranded rna
replication in nucleus (only exception ofr an rna virus)
Paramyxovirus
PARAFLU measles mumps RSV enveloped - non segmented single strand rna reproduce in the cytoplasm
RSV
most common cause of pneumonoia and bronchiolitis in kids less than 1 year
brassy cough, wheezing, winter
supportive
or passive paluizumab during winter
measles (rubeolla)
very infectious affects kids
has high mortality
immunity for life
3 C’s of measles + two other Symp
Coryza, Cough, conjunctivits
+ maculopapular rash
Koplik spots on buccal mucosa
rash not infectious
measles complications
Subacute sclerosing pan encephalitis
pregnancy-
– Premature labor
– Spontaneous abortion
– Low-birth weight infants
Mumps
parotitis
orchitis
aseptic meninigitis
mild in childhood severe in adults
live attenutated vaccine
URT + 1 viremia
Adenovirus
DSDNA virus replicates in nucleus
no envelope
adenovirus clinical presentation
eye, GI, URI
Rhinoviruses
picornavirus family: small + RNA virus no envelope • Virus usually associated with the common cold • Self-limiting infection of URT – Virus replicates best at 33oC
– Acid labile (e.g. can’t passage through stomach) but
resistant to drying and many detergents
• Over 100 serotypes isolated
– Immunity following infection with one serotype does
not prevent infection with other serotypes
• Transmitted by fomites and aerosols
