Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Virology - Final > Retroviridae - Gammaretrovirus: Feline Leukemia Virus and Feline Sarcoma Virus > Flashcards

Retroviridae - Gammaretrovirus: Feline Leukemia Virus and Feline Sarcoma Virus Flashcards

1
Q

Which genus is responsible for Feline Leukemia Virus (FeLV)?

A

Gammaretrovirus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

True/False. FeLV is associated with only neoplastic diseases of cats.

A

False. This highly contagious virus is associated with neoplase and non-neoplastic diseases of cats.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Which gene encodes the p27 protein of FeLV?

A

The gag gene

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Which FeLV viral protein are most seriological assays designed to detect?

A

p27 protein

(also the capsid protein)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Which gene encodes the p15E protein of FeLV?

A

The env gene

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What role does p15E protein play in immunosuppression and facilitation of virus persistence?

A

Suppressed lymphocyte blastogenesis

Blocks the respons of T cells to IL-1 and IL-2

Suppresses the reponse to FOCMA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Which gene encodes the gp70 protein of FeLV?

A

The env gene

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Which viral protein is responsible for attachment of virus to host cells?

A

gp70 protein

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Neutralizing antibodies against which protein offers protection against viremia?

A

gp70

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

How many subgroups of FeLV are there and what are they based on?

A

Based on differences in gp70 protein, there are at least 4 different FeLV subgroups

FeLV-A

FeLV-B

FeLV-C

FeLV-T

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Which subgroup of FeLV is found in all naturally infected viremic cats and is highly contagious?

A

FeLV-A

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Which subgroup of FeLV is the only one that is horizontally transmitted from cat-to-cat?

A

FeLV-A

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

True/False. Cats infected with both FeLV-A and FeLV-B have a higher risk of developing tumors than those infected with FeLV alone.

A

True.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Which FeLV subgroup arises through recombination between FeLV-A and endogenous retroviral genome sequences contained in normal feline DNA?

A

FeLV-B

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Which FeLV subgroup causes immunosuppression and rapidly fatal non-regenerative anemia?

A

FeLV-C

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Which FeLV subgroup arises de-novo as a result of mutations and recombination in receptor binding region of the FeLV-A env gene?

A

FeLV-C

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Which FeLV subgroup is rarely described in literature and exhibits T-cell tropism associated with lymphopenia?

A

FeLV-T

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

What kind of environment would you expect FeLV to survive the longest in?

A

A moist environment (24-48 hrs at room temp)

[dry environment survives only minutes]

[FeLV is extremely liable and rapidly inactivated by common disinfectants]

19
Q

True/False. A cat that is indirectly exposed to FeLV for a short amount of time will contract the virus.

A

FALSE!

Prolonged direct exposure is required for transmission.

20
Q

How is FeLV most commonly transmitted?

A

Occurs primarily through saliva (virus concentration is high)

(also by iatrogenic transmission and in-utero)

21
Q

Where does FeLV mulitply?

A

T and B lymphocytes

22
Q

Were does FeLV initially replicate after infection?

A

The local lymphoid tissue in the oropharyngeal area

23
Q

Infection of leukocytes and platelet precursors takes place where and causes what?

A

Bone marrow

This causes the subsequent release of infected cells in circulation which causes a secondary viremia

24
Q

What stage of FeLV infection do cats have high levels of neutralizing antibodies but never become viremic?

A

Abortive infection

“self limiting infection”

25
Q

Which stage of FeLV infection can cats no longer eliminate the virus from their body and becomes latent?

A

Regressive infection

26
Q

What reactivates a FeLV regressive infection?

A

Immunosuppression (stress ect)

27
Q

Which stage of FeLV infection is associated with extensive viral replication with no containment?

A

Progressive infection

28
Q

True/False. Progressively infected cats remain persistently viremic and are infectious to other cats for life.

A

True

29
Q

Which region of FeLV transactivates cancer-related signaling pathways by activating NF kappa B?

A

U3-LTR

30
Q

Which tumor specific antigen is present only on membranes of cells transformed by FeLV or FeSV?

A

FOCMA (feline oncornavrius-associated cell membrane antigen)

31
Q

Are cats with high levels of FOCMA antibodies resistant to development of leukemia and lymphoma regardless if the test negative or postive for FeLV?

A

Yes

32
Q

True/False. FOCMA antibody neutralizes FeLV.

A

False

FOCMA antibody does not neutralize virus

Cats with FOCMA antibody titers may still be viremic and die from nonmalignant disease

33
Q

Which form of lymphosarcoma is primarily seen in kittens?

A

Thymic (T cell tumor)

34
Q

Which form of lymphosarcoma is present in multiple lymphoid and non-lymphoid organs and tissues?

A

Multicentric (T cell tumor)

35
Q

Which form of lymphosarcoma is usually seen older cats and involves GALT and/or mesenteric lymphnodes?

A

Alimentary lymphosarcoma (B cell tumor)

[cats are usually FeLV neg]

36
Q

Which type of myeloproliferative disease causes abnormal proliferation of erythroid cell lines?

A

Erythromyelosis

37
Q

Which type of myeloproliferative disease causes abnormal proliferation of granulocytic myeloid cells?

A

Granulocytic leukemia

(usually neutrophils)

38
Q

Which type of myeloproliferative disease causes abnormal proliferation of erythroid and granulocytic myeloid precursers?

A

Erythroleukemia

39
Q

Which type of myeloproliferative disease causes abnormal proliferation of fibroblasts and cancerous bone?

A

Myelofibrosis

40
Q

What condition is due to immune complex hypersensitivity, resulting in reactivation of latent infections and secondary bacterial infections?

A

Hypocomplementemia

41
Q

Which kind of vaccines are used agains FeLV and how much does it reduce the incidence of disease?

A

Reduces incidence of disease by 80%

Inactivated vaccine

Canarypox virus carrying FeLV gag and even genes

Genetically engineered vaccine (gp70 subunit vx)

42
Q

Which virus arises from the recombination events between FeLV-A and host cell proto-oncogenes?

A

Feline Sarcoma Virus (FeSV)

43
Q

True/False. All strains of FeSV that cause fibrosarcomas are pseudotypes.

A

True

Virology - Final (8 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions