resting cell membrane Flashcards
why do all cells have potential difference
allows cell signalling by changing the membrane potential e.g nervous system or in cells such as islets of langerhan for the release of insulin
how to measure cell potential
put a negative microelectrode into the cell and run a current and will show a negative potential
what is the range that cells charges usually are
-20mv to -90mv
important cell potentials need to know
skeletal= -90
smooth muscle= -50
neurones= -70
cardiac= -80
how is resting potential set up
in most cells k+ channels are open and k+ leaves town a conc gradient but then re-enters down a potential gradient until an equilibrium is set up and this is where the inside of the cell is negative because more anions left behind in cell
what is the Nernst equation
Ek=61/z(mVlog10 [k+]0/[k+]1. this is were ek is the membrane potential if membrane selectively permeable to K+ alone. once equilibrium is reached k+ don’t move anymore and Ek doesn’t change
what happens if you change the selective permeability of the cell
this is how you increase or decrease the excitability of a cell. muscle cells need a large influx for threshold value to be reached. less for neurones and smooth muscle