Respiratory Viruses Flashcards

1
Q

Describe bronchiolitis

A
  • Occurs in < 2 years old
  • Inflammation and plugging of small bronchioles
  • Caused by RSV
  • Might need oxygen/NIV
  • Rare in first month of life
  • Peak age 2-5 months
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2
Q

What are clinical presentations of respiratory viruses (depending on virus and host)?

A
  • Bronchiolitis
  • Pharyngitis
  • Common cold (rhinorrhea)
  • Croup
  • Pneumonia (primary viral or secondary bacterial)
  • Influenza-like illness
  • Extra-pulmonary illness (gastroenteritis, encephalitis, myocarditis)
  • MERS
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3
Q

How are most viruses spread?

A

Droplet spread (not respiratory route)

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4
Q

What is the incubation period of influenza?

A

1-4 days

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5
Q

What is the incubation period of RSV?

A

2-8 days

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6
Q

What is the incubation period of MERS?

A

< 14 days

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7
Q

What are the three upper respiratory tract infection syndromes?

A

1) Common cold
2) Pharyngitis
3) Laryngitis

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8
Q

What are the key features of common cold?

A
  • Nasal obstruction
  • Nasal discharge
  • Sneezing
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9
Q

What are the key features of pharyngitis?

A
  • Sore throat
  • Inflammation
  • ± exudates
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10
Q

What is the key feature of laryngitis?

A

Hoarseness

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11
Q

What are the three syndromes associated with infection of the major airways?

A

1) Croup (laryngo-tracheo-bronchitis)
2) Tracheobronchitis
3) Bronchiolitis

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12
Q

What are the key features of croup?

A
  • Hoarseness
  • Barking cough
  • Stridor
  • Associated with apnoea
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13
Q

What are the key features of tracheobronchitis?

A
  • Cough

- Substernal pain

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14
Q

What are the key features of bronchiolitis?

A
  • Cough
  • Dyspnoea
  • Wheezing
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15
Q

What is lower respiratory tract infection?

A

Pneumonia/pneumonitis

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16
Q

What are the key features of pneumonia/pneumonitis?

A
  • Cough
  • Dyspnoea
  • Chest pain
  • Rales (crackles)
17
Q

What are the key features of influenza like illness?

A
  • Upper and lower respiratory tract symptoms

- Systemic symptoms - fever, malaise, myalgia, headache, chills

18
Q

What is the common cause of bronchiolitis?

19
Q

What are the common causes of the common cold?

A

Rhinoviruses
Coronaviruses
(Parainfluenza viruses)
Enteroviruses

20
Q

What is the common cause of croup?

A

Parainfluenza viruses

21
Q

What is the common cause of influenza like illness?

A

Influenza viruses

22
Q

What are the common causes of pneumonia?

A

Influenza viruses
RSV
Adenoviruses

23
Q

What is R0?

A

The average number of individuals you will infect if you have that disease

24
Q

How are influenza viruses classified?

25
How is influenza transmitted?
- Coughing and sneezing causes aerosolisation - Large droplets - Direct contact with secretions
26
What are the causes of influenza deaths?
- Secondary bacterial pneumonia - Increases risk of MIs and strokes bc immune response leads to hypercoagulability - Viral pneumonitis
27
How many days before the measles rash can someone be infectious?
4 days
28
When is ECMO used?
When the lungs can't ventilate
29
When is tamiflu/oseltamivir (antiviral) effective?
As a prophylactic agent
30
Why is oseltamivir not v effective once the patient is symptomatic?
- There are a huge number of respiratory tract cells infected which are going to die so stopping replication might not help very much
31
What can measles cause?
Pneumonitis
32
What happens for a year after you have measles?
You have immunoparesis where your immune system is less effective
33
What can CMV cause?
Multifocal patchy pneumonia