Respiratory tract Flashcards

1
Q

What does physical examination of the respiratory tract consist of?

A
  1. inspection of respiratory rate
  2. palpation of tracheal position
  3. tactile fremitus
  4. auscultation
  5. percussion
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2
Q

What are extrapulmonary manifestations of pulmonary disease? (3)

A
  1. acute findings such as cyanosis and altered mental status and signs of chronic respiratory insufficiency such as growth failure, clubbing, and osteoarthropathy
  2. evidence of cor pulmonale (loud pulmonic component of the second heart sound, hepatomegaly, elevated neck veins, and rarely, peripheral edema)
  3. Respiratory disorders - secondary to disease in other systems (metabolic acidosis, congenital heart disease, neuromuscular disease, immunodeficiency, autoimmune disease, and occult malignancy arthritis or hepatosplenomegaly).
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3
Q

When do we do pulmonary function tests?

A

to evaluate obstructive, restrictive lung diseases

Measure disease severity, measure disease progression, and evaluate response to therapy.

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4
Q

The Expert Panel Report recommends pulmonary function testing be performed routinely for …

A

for evaluation and management of asthmatic children age 5 and older.

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5
Q

Obstructive processes include … (3)

A

asthma, bronchopulmonary dysplasia (BPD), and cystic fibrosis (CF).

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6
Q

Restrictive lung disease can be caused by … (3)

A

chest wall deformities that limit lung expansion, muscle weakness, and
interstitial lung diseases such as collagenvascular diseases, hypersensitivity pneumonitis, and interstitial fibrosis.

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7
Q

Confirmation of restrictive lung or chest wall physiology requires …

A

lung volume measurements (total lung capacity, residual volume, and functional residualcapacity) because poor effort can mimic restrictive physiology).

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8
Q

Blood gas measurements are used to evaluate … (3)

A

hypoxemia, acidosis, hypercarbia

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9
Q

Blood gas measurements can be used to categorize acid-base disturbances as … (3)

A

respiratory, metabolic, mixed

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10
Q

Blood gas measurements are affected by … (4)

A

abnormalities of respiratory control,
gas exchange,
respiratory mechanics, and
the circulation.

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11
Q

Causes of hypoxemia (3)

A

hypoventilation, shunts, and diffusion barrier for oxygen.

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12
Q

Hypercapnia results from … (3)

A

hypoventilation due to:
decreased central respiratory drive,
respiratory muscle weakness, and
low-tidal-volume breathing as seen in restrictive lung diseases, severe scoliosis, or chest wall trauma

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13
Q

Venous blood gas analysis or capillary blood gas analysis can be useful for the assessment of … but not …

A

Venous blood gas analysis or capillary blood gas analysis can be useful for the assessment of Pco2 and pH, but not Po2 or saturation.

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14
Q

The pulse oximeter has reduced reliability during conditions causing reduced arterial pulsation such as … 3

A

hypothermia, hypotension, or infusion of vasoconstrictor drugs.

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15
Q

Sources of respiratory tract secretions for diagnostic testing include: (5)

A

nasopharyngeal and oropharyngeal swabs; expectorated and induced sputum;
tracheal aspirates;
direct lung or pleural fluid sampling; bronchoalveolar lavage fluid;
and gastric aspirates, for M tuberculosis.

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16
Q

imaging of the respiratory tract

A
  1. radiograph for chest wall abnormalities, heart, diaphram, lung parenchyma
  2. lateral neck radiograph +/- barium swallowing
  3. airway fluroscopy to asses both fixed airway obstruction and dynamic airway obstruction
  4. chest CT
  5. MRI
  6. laryngoscopy and bronchoscopy
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17
Q

what is oxygen therapy for

A

to relive hypoxemia: supplemental oxygen can reduce the work of breathing, relax pulmonary vasculature

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18
Q

describe the therapy with inhalation of medications

A

used routinely with chronic disease such as CF, bronchopulmonary dysplasia, asthma, acute illnesses

SABA and anticholinergics for acute bronchodilation
inhaled corticosteroids and cromones : antiinflammatory effects (controllers)
nebulized antibiotics

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19
Q

what is airway clearance therapy

A

chest physical therapy with postural drainage, percussion and forced expiratory maneuvers for clearance of lower airway secretions in children with CF, bronchiectasis and neuromuscular disorders

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20
Q

Extrathoracic or upper airway obstruction disrupts the _____ phase of respiration and is often manifest by _____.

A

inspiratory phase; stridor or noisy breathing

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21
Q

intrathoracic obstruction disrupts the ____ phase of respiration and is often manifest by ____

A

expiratory phase
wheezing and rpoongation of the expiratory phase

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22
Q

after assessing whether the obstruction is extrathoracic or intrathoracic, the next challange is ….

A

to determine if the obstruction is fixed or variable

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23
Q

sounds in variable obstruction:

A

dofter or absent with normal quiet breathing and sound different with hevery breath

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24
Q

clinical indication that teh obstruction is severe:

A

hig-pitched stridor or wheezing, biphasic stridor, dorroling or dysphagia, poor intensity breath sounds, severe retractions and poor color or cynosis

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25
Q

How do we most successfully remove foreign body?

A

using a rigid bronchoscopy under general anaesthesia

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26
Q

Croup is…

A

Croup describes acute inflammatory diseases of the larynx, including viral croup (laryngotracheobronchitis), epiglottitis (supraglottitis), and bacterial tracheitis.

27
Q

describe cystic fibrosis

A
  • Greasy, bulky, malodorous stools; failure to thrive.
  • Recurrent respiratory infections.
  • Digital clubbing on examination.
  • Bronchiectasis on chest imaging.
  • Sweat chloride > 60 mmol/L.
  • autosomal recessive disease,
  • syndrome of chronic sinopulmonary infections, malabsorption and nutritional abnormalities
  • one of the most common lethal genetic diseases
  • abnormalities occur in the hepatic, gastrointestinal, and male reproductive systems, lung disease is the major cause of morbidity and mortality
    Most individuals with CF develop obstructive lung disease associated with chronic infection that leads to progressive loss of pulmonary function.
28
Q

Cause of CF

A

defect in a single gene on chromosome 7 that encodes an epithelial chloride channel called the CF transmembrane conductance regulator (CFTR) protein.

most common mutation is delta F508

29
Q

________ is virtually diagnostic of CF, so the infant should be treated presumptively as having CF until a sweat test or genotyping can be obtained.

A

meconium ileus

30
Q

____________ occurs in more than 85% of persons with CF.

A

Pancreatic insufficiency occurs in more than 85% of persons with CF.

31
Q

CF lab findings

A

sweat chloride concentration greater than 60 mmol/L in the presence of one or more typical clinical features

32
Q

Treatment of cystic fibrosis

A

pancreatic enzyme supplementation combined with a high calorie, high protein, and high fat diet, daily multivitamins that contain vitamins A, D, E, and K.

Daily salt supplementation, airway clearance therapy and aggressive antibiotic use

33
Q

Symptoms and clinical findings of community-acquired bacterial pneumonia

A

fever (over 39C) cough dyspena
crackles or decreased breath sounds
infiltrates, jilar adenopathy, pleural effusion

34
Q

Laboratory findings of community acquired pneumonia

A

elevated peripheral white blood cell count with left shift, blood cultures, sputum cultures

35
Q

what lab technique do we use to detect wide variety of viral infections

A
  • antigent immunofluoroscent staining and PCR
36
Q

On chest x-ray, interstitial or peribrocnhial infiltrates suggest ____ infection

A

viral

37
Q

Resting heart rate in children

A

<1 month; 80-160
1-3mo 80-200
2-24 mo 70-120
2-10y 60-90
11-18y 40-90

38
Q

All murmors should be desribed based on the following characteristics (40)

A
  1. location and radiation
  2. relationship to cardiac cycle and duration
  3. intensity
  4. quality
  5. variation with position
39
Q

Systolic pressure in the lower extremities should be_____ to that in the upper extremities.

A

greater than or equal to

40
Q

edema of lower extremities in the older child and the face and sacrum in the younger child is characteristic of ________, which may be seen with _________

A

elevated right heart pressure,

tricuspid valve pathology or heart failure

41
Q

How does ECG evolve with age

A

The heart rate decreases and intervals increase with age.
RV dominance in the newborn changes to LV dominance in the older infant, child, and adult.

42
Q

Do heart murmus in first days of life signify structural heart problems?

A

no

43
Q

What murmur is likely to be pathologic

A

loud (grade 3+/6), harsh, or diastolic murmur

44
Q

murmus present at birth signifies

A

a valvular problem

45
Q

Disorders asscoiated with right axis deviation

A

tetralogy of fallot
transposition of the great arteries
total anomalous pulmonary venous return
atrial septal defect

46
Q

disorders associated with left axis deviation

A

atriventricular spetal defect
pulmonary atresia with intact ventricular septum
tricuspid atresia

47
Q

Increased oxygen tension, rhythmic lung distention, and production of nitric oxide as well as prostacyclin play major roles in the fall in pulmonary vascular
resistance at birth. This leads to….

A

The pulmonary vascular resistance falls below that of the systemic circuit, resulting in
a reversal in direction of blood flow across the ductus arteriosus and marked increase in pulmonary blood flow.

48
Q

Functional closure of the ductus arteriosus begins when?

A

shortly after biths (in the first hour)

49
Q

What is persistent pulmonaty hypertension

A

Persistent pulmonary hypertension is a clinical syndrome of full-term infants. The neonate develops tachypnea, cyanosis, and pulmonary hypertension during the first 8 hours after delivery. These infants have massive right-to-left ductal and/or foramen shunting for 3–7 days because of high pulmonary vascular resistance.

50
Q

How to reverse persistent pulmonary hypertension

A

Increased alveolar Po2 with hyperventilation, alkalosis, paralysis, surfactant administration, high-frequency ventilation, and cardiac inotropes

51
Q

Left ventricular volume overload occurs with …

A

any left-toright shunting lesion (eg, VSD, PDA), aortic insufficiency, or a systemic arteriovenous malformation.

52
Q

Causes of right ventricular failure as a result of pressure overload include…

A

pulmonary hypertension, valvar pulmonary stenosis, or severe branch pulmonary artery stenosis.

53
Q

Left ventricular pressure overload results from

A

left heart obstructive lesions such as aortic stenosis (subvalvar, valvar, or supravalvar) or coarctation of the aorta.

54
Q

Children with HF present with …

A

irritability, diaphoresis with feeds, fatigue, exercise intolerance, or evidence of pulmonary congestion!

55
Q

Gold standard diagnostic or therapeutic approach to HF in children

A

no gold standard

56
Q

Treatment: afterload reduction

A

milrinone - phosphodiasterase 3 inhibitor

nitroglycerin

57
Q

treatment enhacement of contractility

A

dopamine
dobutamine

58
Q

overall treatment for heart failure

A
  1. afterload reduction
  2. enhancement of contractility
  3. mechanical circulatory support
  4. diuretics
  5. fluid restriction
59
Q

what is atrial septal defect

A

acyanotic congential heart disease,
Atrial septal defect (ASD) is an opening in the atrial septum permitting the shunting of blood between the atria.

60
Q

three major types of atrial septal defect

A

ostium secundum, ostium primum, and sinus venosus

61
Q

clinical findings: atrial spetal defect

A

with exercise intolerance, easy fatigability, heart failure.

62
Q

diagnosis of atrial septal defect

A

radiograph: cardiac enlargement
ECG: right axis deviation
echocardiography - dilated right atrium and rV

63
Q

treatment of atrial septal defect

A

surgical or cathetarization closure

64
Q

what is ventricular septal defect and what are its clinical features

A

Left-to-right shunt with normal pulmonary vascular resistance.

Clinical features are failure to thrive, tachypnea, and diaphoresis with feeds.