Respiratory: Tobacco Cessation Flashcards

1
Q

The 5 A’s

A
Ask
Advise
Assess
Assist
Arrange
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2
Q

Ask….

A

about tobacco use

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3
Q

Advise….

A

tobacco users to quit

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4
Q

Assess….

A

readiness to make a quit attempt

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5
Q

Assist….

A

with the quit attempt

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6
Q

Arrange…

A

follow up care

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7
Q

Nicotine absorption

A

in acidic media…ionized = poorly absorbed

in alkaline media…nonionized = well absorbed

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8
Q

Pharmacology Factors quitting smoking

A

Alleviation of withdrawal symptoms
Weight Control
Pleasure, mood modulation

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9
Q

Environment Factors

A

Tobacco advertising
Conditioned Stimuli
Social interactions

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10
Q

Environment Factors

A

Tobacco advertising
Conditioned Stimuli
Social interactions

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11
Q

Most notable CYP interaction with smoking?

A

induction CYP1A2, due to hydrocarbons not the actual nicotine

reducing effects of drugs metabolized by CYP1A2

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12
Q

By how much should you reduce caffeine intake when quitting smoking?

A

~50%

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13
Q

Smoking DDI with hormonal contraceptives?

A

increased risk of serious CV adverse effects…stroke, MI, thromboembolism. doesn’t effect effectiveness of contraceptive

esp women 35+

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14
Q

benefits of quitting smoking best at what age?

A

any age, no matter when pt will see benefits

earlier the better

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15
Q

How many years do you get back when you quit

A

Average about 10 if quit at 40

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16
Q

Most popular cessation program

A

1-800-QUITNOW

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17
Q

What are tobacco Quit-lines

A

Free to everyone, staffed locally and offers personalized sessions

better success rate than trying alone

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18
Q

Withdrawal from smoking occurrence

A

most symptoms manifest within first 1-2 days, peak 1st week and subside after 2-4 weeks

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19
Q

Withdrawal from smoking occurrence

A

most symptoms manifest within first 1-2 days, peak 1st week and subside after 2-4 weeks

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20
Q

Nicotine Replacement Therapy precautions

A

recent MI within last 2 weeks
Serious arrhythmias
Serious or worsening angina

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21
Q

How to choose between 2mg or 4mg dose for Nicotine Gum or Lozenge?

A

Based on time to first cigarette

2mg = smod >30min waking up
4mg = smoke <30min of waking up
22
Q

How to choose between 2mg or 4mg dose for Nicotine Gum or Lozenge?

A

Based on time to first cigarette

2mg = smoke >30min waking up
4mg = smoke <30min of waking up
23
Q

Recommended Gum and Lozenge Dosing

A

Weeks 1-6 = 1 piece q1-2h
Weeks 7-9 = 1 piece q2-4h
Weeks 10-12 = 1 piece q4-8h

24
Q

Max lozenges per day?

25
Max gum per day?
24
26
Directions for using nicotine gum
Chew slowly Stop chewing at 1st sign of peppery taste/tingle Park between cheek/gum Chew again when peppery taste/tingle fades
27
Directions for nicotine lozenge
Don't chew or swallow move around mouth
28
Minimum of gm/lozenge should be used in 1st 6 weeks?
9 pieces per day to improve changes of quitting
29
Nicotine gum/lozenge additional info
won't have same rapid satisfaction that smoking provides avoid acidic beverages before/after 15min
30
Adverse effects of nicotine gum
jaw muscle ache | may stick to dental work
31
How to decide dosing of nicotine patch
based on cigarettes per day ``` <10 = Step 2 (14mg X 6 wk), Step 3 (7mg X 2 wk) >10 = Step 1 (21mg X 6 wk), Step 2 (14mg X 2 wk), Step 3 (7mg X 2 week) ``` **NicoDerm CQ**
32
How to decide dosing of nicotine patch
based on cigarettes per day ``` <10 = Step 2 (14mg X 6 wk), Step 3 (7mg X 2 wk) >10 = Step 1 (21mg X 6 wk), Step 2 (14mg X 2 wk), Step 3 (7mg X 2 week) ``` **NicoDerm CQ**
33
Directions of Patch use
use skin on upper body or upper outer part of arm make sure skin is clean Apply to different area each day, don't reuse area for ~ week Don't use for more than 24hrs Don't cut the patch Remove before MRI
34
Nicotine Patch side effects
some skin effects Insomnia and Vivid dreams/abnormal dreams
35
Nicotine Inhaler (RX)
used kinda like a cigarette puff like pipe, want to absorb into oral mucosa
36
Bupropion SR clinical effects
degrees craving for cigarette | decrease symptoms of nicotine withdrawal
37
Bupropion SR pharmacokinetics
extensive CYP2B6 metabolism 1/2 life = 21hrs, metabolites 20-37 8 days for Css
38
Bupropion contraindications
seizure disorder current or prior diagnosis of bulimia or anorexia undergoing abrupt discontinuation of Alc, Benzo, Barbs, antiseptics don't take w/ MAOi or within 14 days of stoping
39
Bupropion Warnings & Precautions
change in mood, suicidal thoughts, neuropsychiatric symptoms.contact provider if experience them FDA black box warning removed 2016
40
Bupropion SR Dosing
begin 1-2 weeks before quit date initial treatment: 150mg po q AM fr 3 days, then 150mg po BID for 7-12 wks. must give dose at least 8hrs apart, no taper when end
41
Common Bupropion SR side effects
insomnia - avoid bedtime dry mouth nausea
42
Advantages Bupropion SR
might delay weight gain oral dosing is easy benefit those with depression relatively cheap
43
Disadvantages Bupropion SR
seizure risk increased contraindications and precautions in some patients monitor for neuropsychiatric symptoms
44
Varenicline clinical effects
decrease symptoms of nicotine withdrawal blocks dopaminergic stimulation responsible for reinforcement and reward associated with smoking
45
Varenicline Warnings and precautions
had black box then removed watch for neuropsychiatric events
46
Varenicline Side effects
rare but have not been causally linked
47
Varenicline Dosing
Start 1 week prior to quit date Day 1-3 = 0.5mg qd Day 4-7 = 0.5mg bid Day 8-end (~8 wks) = 1mg bid
48
Fixed Quit approach
set quit date for 1 wk after starting varenicline | continue treatment for 12 weeks
49
Flexible Quit approach
Start taking and ick a quit date between 8-35 days rom treatment initiation continue for 12 weeks
50
Gradual Quit approach
start taking and reduce smoking by 50% within 1st 4 weeks, an additional 50% in next 4 weeks and continue until complete abstinence by 12 weeks
51
Varenicline additional info
Doses should be taken after eating with a full glass of water Nausea/Insomnia usually temporary SE Can experience wild and vivid dreams
52
1st line for smoking cessation
Varenicline or NRT combo