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DT III Exam 2 > Respiratory pharm > Flashcards

Respiratory pharm Flashcards

1
Q

Front line drugs for Asthma and COPD

A

Beta2 agonist.
Muscarinic receptor antagonist.
Corticosteroids.

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2
Q

Short acting Beta2 agonists (SABA)

A

For immediate asthma rescue therapy

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3
Q

Long acting Beta2 agonists (LABA)

A

Prophylaxis therapy for Asthma (used daily)

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4
Q

Overuse of Albuterol inhaler indicates

A

Need for anti-inflammatory therapy (corticosteroids)

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5
Q

LABA have to be given with what

A

Anti-inflammatory drug

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6
Q

Overusing Beta2 agonists result in (ADR)

A

Overstimulated Beta receptor effects.

Tremor, Tachycardia, Hypokalemia, Toleranece

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7
Q

Muscarinic antagonists used for

A

COPD

not much for Asthma

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8
Q

Acetylcholine does what to lung

A

Stimulate bronchial smooth muscle cells contraction.

Increase mucus production by glands

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9
Q

Leukotriene inhibitors (in general)

A

Not front line therapy

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10
Q

Omalizumab use

A

Severe asthma (not front line)

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11
Q

Omalizumab MoA

A

Humanized monoclonal antibody against IgE.

Inhibit IgE binding to IgE receptors on mast cells

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12
Q

Mucolytic agents are adjunct therapy for

A

Cystic fibrosis

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13
Q

Theophylline cautions

A 
Low therapeutic index. 
CYP interaction
Adverse effects are dose dependent. 
Low: Nausea, vomiting, headache, restlessness.
High: Cardiac arrhythmia, Seizures.
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14
Q

Theophylline use

A

COPD (not front line treatment though)

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15
Q

Early onset COPD caused by

A

Alpha 1 proteinase inhibitor

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16
Q

Treatment of Alpha1 proteinase inhibitor deficiency

A

Administer recombinant alpha-1 proteinase inhibitor

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17
Q

Adrenergic agonist use

A

Reverse nasal congestion.

(Constrict swollen nasal mucosa by activation of Alpha 1 receptor in nasal tissue

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18
Q

Adrenergic agonist ADR

A

Cardiovascular ADR.

Rebound nasal congestion

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19
Q

Cough suppression by

A

Low dose opioids.
Dextromethorphan (NMDA receptor antagonist.
Benzonatate

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20
Q

Benzonatate MoA

A

Suppress cough receptors in airway

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21
Q

Low dose opioid MoA

A

Suppress central mechanism for cough

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22
Q

Dextromethorphan MoA

A

NMDA receptor antagonist

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23
Q

Antitussive agent side effects

A

Respiratory depression, CNS depression, Dizziness

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24
Q

Test for Asthma

A

Methacholine challenge test

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25
Q

Genetic risk factor for COPD

A

Alpha 1 protease inhibitor deficiency

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26
Q

Albuterol

A

SABA

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27
Q

Terbutaline

A

SABA

28
Q

Pirbuterol

A

SABA

29
Q

Metaproterenol

A

SABA

30
Q

Isoproterenol MoA

A

Nonselective Beta agonist and potent bronchodilator

31
Q

Isoproterenol use

A

Acute asthma attack

32
Q

Epinephrine use

A

Acute asthma attack and Anaphylaxis

33
Q

Isoproterenol/ Epinephrine ADR

A

Tachycardia, Arrhythmias, Angina

34
Q

Salmeterol

A

LABA

35
Q

Formoterol

A

LABA

36
Q

Indacaterol

A

LABA

37
Q

Ipratropium

A

Muscarinic antagonist

38
Q

Tiotropium

A

Muscarinic antagonist

39
Q

Popular combination inhaler for COPD

A

Ipratropium/ Albuterol

40
Q

Muscarinic antagonist ADR

A

Unpleasant bitter taste, Dry mouth, Glaucoma if sprayed

41
Q

Theophylline MoA

A

PDE inhibitor, Adenosine receptor antagonist, Anti-inflammatory, Promote diaphragmatic muscle contraction

42
Q

Beclomethasone

A

Corticosteroid

43
Q

Triamcinolone acetate

A

Corticosteroid

44
Q

Budesonide

A

Corticosteroid

45
Q

Fluticasone propionate

A

Corticosteroid

46
Q

Corticosteroid use

A

Front line therapy for persistent asthma.

Allergic rhinitis

47
Q

Corticosteroid ADR

A

Dysphonia, Cough, Oropharyngeal candidiasis

48
Q

Zafirlukast

A

Leukotriene inhibitor

49
Q

Montelukast

A

Leukotriene inhibitor

50
Q

Leukotriene inhibitor use

A

Allergic rhinitis

Propylaxis of mild persistent asthma

51
Q

Zileuton MoA

A

Inhibit 5-lipoxygenase

52
Q

Leukotriene inhibitor ADR

A

Hepatic toxicity

CYP inhibitor

53
Q

Cromolyn

A

Mast cell stabilizer

54
Q

Nedocromil

A

Mast cell stabilizer

55
Q

Omalizumab ADR

A

Anaphylaxis

56
Q

Alpha1 proteinase inhibitor MoA

A

Inhibit elastase activity

57
Q

Hydrocodone

A

Opioid

58
Q

Codeine

A

Opioid

59
Q

Guaifenesin

A

Expectorant

60
Q

Guifenesin ADR

A

Emetic

61
Q

N-acetylcysteine

A

Mucolytic, cleaves disulfide bonds of mucus glycoprotein

62
Q

Dornase alpha

A

Mucolytic, DNAse

63
Q

Mucolytic

A

N acetylcysteine, Dornase alpha

64
Q

Phenylephrine

A

Adrenergic agonist, alpha 1

65
Q

Oxymetazoline

A

Adrenergic agonist, alpha

66
Q

Pseudoephedrine

A

Adrenergic agonist, alpha and beta

DT III Exam 2 (2 decks)

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